Volume 5B - Army Financial Management - U.S. Army

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UNCLASSIFIEDExhibit R-2, RDT&E Budget Item Justification: PB 2012 Army DATE: February 2011APPROPRIATION/BUDGET ACTIVITY2040: Research, Development, Test & Evaluation, ArmyBA 5: Development & Demonstration (SDD)R-1 ITEM NOMENCLATUREPE 0604807A: Medical Materiel/Medical Biological Defense Equipment - Eng Devproducts placed into the hands of medical providers or service members for human use. Products from this project will normally transition to DoD Health Programs orOPA funds.This program is managed by U.S. Army Medical Materiel Development Activity (USAMMDA) and U.S. Army Medical Materiel Agency (USAMMA) of the US ArmyMedical Research and Materiel Command.B. Program Change Summary ($ in Millions) FY 2010 FY 2011 FY 2012 Base FY 2012 OCO FY 2012 TotalPrevious President's Budget 41.794 34.474 30.059 - 30.059Current President's Budget 37.572 34.474 27.160 - 27.160Total Adjustments -4.222 - -2.899 - -2.899• Congressional General Reductions -• Congressional Directed Reductions -• Congressional Rescissions - -• Congressional Adds -• Congressional Directed Transfers -• Reprogrammings -3.099 -• SBIR/STTR Transfer -1.123 -• Adjustments to Budget Years - - -2.899 - -2.899UNCLASSIFIEDArmy Page 2 of 27 R-1 Line Item #111Volume 5B - 195
UNCLASSIFIEDExhibit R-2A, RDT&E Project Justification: PB 2012 Army DATE: February 2011APPROPRIATION/BUDGET ACTIVITY2040: Research, Development, Test & Evaluation, ArmyBA 5: Development & Demonstration (SDD)COST ($ in Millions)FY 2010 FY 2011FY 2012BaseR-1 ITEM NOMENCLATUREPE 0604807A: Medical Materiel/MedicalBiological Defense Equipment - Eng DevFY 2012OCOPROJECT812: MIL HIV VAC&DRUG DEVFY 2012Total FY 2013 FY 2014 FY 2015 FY 2016Cost ToComplete Total Cost812: MIL HIV VAC&DRUG DEV 4.296 4.456 3.866 - 3.866 2.949 4.329 4.490 4.486 Continuing ContinuingQuantity of RDT&E ArticlesA. Mission Description and Budget Item JustificationThis project funds militarily relevant human immunodeficiency virus (HIV) medical countermeasures. These funds provide for engineering and manufacturingdevelopment of candidate vaccines and drugs to permit large-scale field testing. Development is focused on militarily unique needs effecting manning, mobilization,and deployment.The major contractor is The Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD. Research efforts are coordinated with the NationalInstitutes of Health.B. Accomplishments/Planned Programs ($ in Millions, Article Quantities in Each) FY 2010 FY 2011 FY 2012Title: Military HIV Vaccine and Drug DevelopmentDescription: This project provides funds for engineering and manufacturing development of candidate vaccines and drugs topermit large-scale field testing of vaccines for medical countermeasures to HIV.Articles:FY 2010 Accomplishments:prepared preliminary clinical study report on the completed expanded safety/efficacy trial in Thailand and conduct a critical designreview (CDR) to determine future development of the prime-boost vaccine based on trial results. Follow up clinical trial for HIVpositive for viral load in order to validate viral load as a surrogate endpoint for use in HIV vaccine studies.FY 2011 Plans:Finalize and submit to the Food and Drug Administration (FDA) results from the expanded safety/efficacy trial in Thailand, update/revise the clinical development plan, and continue to follow up clinical trial for HIV positive for viral load.FY 2012 Plans:Perform three inter-related studies to enhance our understanding of precisely how the vaccine strategy used in the safety/efficacytrial completed in 2009 caused vaccine recipients to be protected from infection, including intense laboratory studies usingsamples from the trial, and commencement of two small clinical vaccine trials to generate data and samples to hopefully definewhat vaccine responses to try to generate for next increment studies.4.29604.45603.866Accomplishments/Planned Programs Subtotals 4.296 4.456 3.866UNCLASSIFIEDArmy Page 3 of 27 R-1 Line Item #111Volume 5B - 196
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UNCLASSIFIEDDepartment of DefenseFi
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UNCLASSIFIEDFY 2012 RDT&E, ARMYPROG
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Tractor Eggs0603131/DS9*High Perfor
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UNCLASSIFIEDDepartment of the ArmyF
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Appropriation: 2040 ALineNoProgramE
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UNCLASSIFIEDArmy • President's Bu
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BA# 05: Development & Demonstration
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UNCLASSIFIEDExhibit R-2, RDT&E Budg
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UNCLASSIFIEDExhibit R-4A, RDT&E Sch
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