REFERENCES1 Metzler, R. & Klafter, J. When translocation dynamics becomes anomalous. Biophysical Journal 85, 2776-2779, doi:10.1016/s0006-3495(03)74699-2 (2003).2 Duncan, R. & Izzo, L. Dendrimer biocompatibility and toxicity. Advanced Drug Delivery Reviews 57, 2215-2237, doi:10.1016/j.addr.2005.09.019 (2005).3 Chavanpatil, M. D., Khdair, A. & Panyam, J. Surfactant-polymer nanoparticles: A novel platform forsustained and enhanced cellular <strong>de</strong>livery of water-soluble molecules. Pharmaceutical Research 24, 803-810, doi:10.1007/s11095-006-9203-2 (2007).4 Cao, Y. W. C., Jin, R. C. & Mirkin, C. A. Nanoparticles with Raman spectroscopic fingerprints for DNA andRNA <strong>de</strong>tection. Science 297, 1536-1540, doi:10.1126/science.297.5586.1536 (2002).5 Elghanian, R., Storhoff, J. J., Mucic, R. C., Letsinger, R. L. & Mirkin, C. A. Selective colorimetric <strong>de</strong>tection ofpolynucleoti<strong>de</strong>s based on the distance-<strong>de</strong>pen<strong>de</strong>nt optical properties of gold nanoparticles. Science 277,1078-1081, doi:10.1126/science.277.5329.1078 (1997).6 Jaiswal, J. K., Goldman, E. R., Mattoussi, H. & Simon, S. M. Use of quantum dots for live cell imaging.Nature Methods 1, 73-78, doi:10.1038/nmeth1004-73 (2004).7 Michalet, X. et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307, 538-544,doi:10.1126/science.1104274 (2005).8 Chen, X., Kis, A., Zettl, A. & Bertozzi, C. R. A cell nanoinjector based on carbon nanotubes. Proceedings ofthe National Aca<strong>de</strong>my of Sciences of the United States of America 104, 8218-8222,doi:10.1073/pnas.0700567104 (2007).9 Kam, N. W. S. & Dai, H. J. Carbon nanotubes as intracellular protein transporters: Generality and biologicalfunctionality. Journal of the American Chemical Society 127, 6021-6026, doi:10.1021/ja050062v (2005).10 Leroueil, P. R. et al. Nanoparticle interaction with biological membranes: Does nanotechnology present ajanus face? Accounts of Chemical Research 40, doi:10.1021/ar600012y (2007).11 Roiter, Y. et al. Interaction of nanoparticles with lipid membrane. Nano Letters 8, 941-944,doi:10.1021/nl0800801 (2008).12 Yang, K. & Ma, Y. Q. Computer simulation of the translocation of nanoparticles with different shapesacross a lipid bilayer. Nature Nanotechnology 5, 579-583, doi:10.1038/nnano.2010.141 (2010).13 Verma, A. et al. Surface-structure-regulated cell-membrane penetration by monolayer-protectednanoparticles. Nature Materials 7, doi:10.1038/nmat2202 (2008).14 Mukherjee, S., Ghosh, R. N. & Maxfield, F. R. Endocytosis. Physiological Reviews 77, 759-803 (1997).15 Kirchhausen, T. Three ways to make a vesicle. Nature Reviews Molecular Cell Biology 1, 187-198,doi:10.1038/35043117 (2000).16 Gao, H. J., Shi, W. D. & Freund, L. B. Mechanics of receptor-mediated endocytosis. Proceedings of theNational Aca<strong>de</strong>my of Sciences of the United States of America 102, 9469-9474,doi:10.1073/pnas.0503879102 (2005).17 Smith, K. A., Jasnow, D. & Balazs, A. C. Designing synthetic vesicles that engulf nanoscopic particles.Journal of Chemical Physics 127, doi:10.1063/1.2766953 (2007).18 Lerner, D. M., Deutsch, J. M. & Oster, G. F. HOW DOES A VIRUS BUD. Biophysical Journal 65, 73-79 (1993).19 Zhang, S., Li, J., Lykotrafitis, G., Bao, G. & Suresh, S. Size-Depen<strong>de</strong>nt Endocytosis of Nanoparticles.Advanced Materials 21, doi:10.1002/adma.200801393 (2009).20 Ding, H.-m., Tian, W.-d. & Ma, Y.-q. Designing Nanoparticle Translocation through Membranes byComputer Simulations. Acs Nano 6, 1230-1238, doi:10.1021/nn2038862 (2012).21 Lee, H. & Larson, R. G. Multiscale Mo<strong>de</strong>ling of Dendrimers and Their Interactions with Bilayers andPolyelectrolytes. Molecules 14, 423-438, doi:10.3390/molecules14010423 (2009).22 Ting, C. L. & Wang, Z. G. Interactions of a Charged Nanoparticle with a Lipid Membrane: Implications forGene Delivery. Biophysical Journal 100, 1288-1297, doi:10.1016/j.bpj.2010.11.042 (2011).23 Ginzburg, V. V. & Balijepailli, S. Mo<strong>de</strong>ling the thermodynamics of the interaction of nanoparticles with cellmembranes. Nano Letters 7, 3716-3722, doi:10.1021/nl072053l (2007).24 Nel, A. E. et al. Un<strong>de</strong>rstanding biophysicochemical interactions at the nano-bio interface. Nature Materials8, 543-557, doi:10.1038/nmat2442 (2009).100
25 Tyagi, P. et al. Dynamic Interactive Membranes with Pressure-Driven Tunable Porosity and Self-HealingAbility. Angewandte Chemie-International Edition 51, 7166-7170, doi:10.1002/anie.201201686 (2012).26 Wright, A. K. & Thompson, M. R. Hydrodynamic structure of bovine serum-albumin <strong>de</strong>termined bytransient electric birefringence. Biophysical Journal 15, 137-141 (1975).27 Allen, T. & Khan, A. A. Critical evaluation of pow<strong>de</strong>r sampling procedures. Chemical Engineer-London,C108-& (1970).28 Wang, X.-D. et al. Preparation of spherical silica particles by Stober process with high concentration oftetra-ethyl-orthosilicate. Journal of Colloid and Interface Science 341, doi:10.1016/j.jcis.2009.09.018(2010).29 Kotsev, S. & Kolomeisky, A. B. Translocation of polymers with fol<strong>de</strong>d configurations across nanopores. TheJournal of chemical physics 127, doi:10.1063/1.2800008 (2007).30 Muthukumar, M. Translocation of a confined polymer through a hole. Physical Review Letters 86, 3188-3191, doi:10.1103/PhysRevLett.86.3188 (2001).31 Slonkina, E. & Kolomeisky, A. B. Polymer translocation through a long nanopore. Journal of ChemicalPhysics 118, doi:10.1063/1.1560932 (2003).32 Palecek, S. P. & Zydney, A. L. Intermolecular electrostatic interactions and their effect on flux and protein<strong>de</strong>position during protein filtration. Biotechnology Progress 10, 207-213, doi:10.1021/bp00026a010(1994).33 Ho, C. C. & Zydney, A. L. Effect of membrane morphology on the initial rate of protein fouling duringmicrofiltration. Journal of Membrane Science 155, 261-275, doi:10.1016/s0376-7388(98)00324-x (1999).34 Ho, C. C. & Zydney, A. L. A combined pore blockage and cake filtration mo<strong>de</strong>l for protein fouling duringmicrofiltration. Journal of Colloid and Interface Science 232, 389-399, doi:10.1006/jcis.2000.7231 (2000).35 Huisman, I. H., Pradanos, P. & Hernan<strong>de</strong>z, A. The effect of protein-protein and protein-membraneinteractions on membrane fouling in ultrafiltration. Journal of Membrane Science 179, 79-90,doi:10.1016/s0376-7388(00)00501-9 (2000).36 Wang, P., Tan, K. L., Kang, E. T. & Neoh, K. G. Plasma-induced immobilization of poly(ethylene glycol) ontopoly(vinyli<strong>de</strong>ne fluori<strong>de</strong>) microporous membrane. Journal of Membrane Science 195, 103-114,doi:10.1016/s0376-7388(01)00548-8 (2002).37 Ostuni, E., Chapman, R. G., Holmlin, R. E., Takayama, S. & Whitesi<strong>de</strong>s, G. M. A survey of structure-propertyrelationships of surfaces that resist the adsorption of protein. Langmuir 17, 5605-5620,doi:10.1021/la010384m (2001).38 Pasche, S., Voros, J., Griesser, H. J., Spencer, N. D. & Textor, M. Effects of ionic strength and surface chargeon protein adsorption at PEGylated surfaces. Journal of Physical Chemistry B 109, 17545-17552,doi:10.1021/jp050431+ (2005).39 Rixman, M. A., Dean, D. & Ortiz, C. Nanoscale intermolecular interactions between human serum albuminand low grafting <strong>de</strong>nsity surfaces of poly(ethylene oxi<strong>de</strong>). Langmuir 19, 9357-9372, doi:10.1021/la0340571(2003).40 Jacobs, R. E. & White, S. H. Behavior of hexane dissolved in dioleoylphosphatidylcholine bilayers - an nmrand calorimetric study. Journal of the American Chemical Society 106, 6909-6912,doi:10.1021/ja00335a006 (1984).41 Mul<strong>de</strong>rs, F., Vanlangen, H., Vanginkel, G. & Levine, Y. K. The static and dynamic behavior of fluorescentprobemolecules in lipid bilayers. Biochimica Et Biophysica Acta 859, 209-218, doi:10.1016/0005-2736(86)90216-6 (1986).42 Adler, M. & Tritton, T. R. Fluorescence <strong>de</strong>polarization measurements on oriented membranes. BiophysicalJournal 53, 989-1005 (1988).43 McIntosh, T. J., Simon, S. A. & Macdonald, R. C. The organization of normal-alkanes in lipid bilayers.Biochimica Et Biophysica Acta 597, 445-463, doi:10.1016/0005-2736(80)90219-9 (1980).44 Salafsky, J. S. & Eisenthal, K. B. Second harmonic spectroscopy: <strong>de</strong>tection and orientation of molecules at abiomembrane interface. Chemical Physics Letters 319, 435-439, doi:10.1016/s0009-2614(00)00116-0(2000).45 Xiang, T. X. & An<strong>de</strong>rson, B. D. Liposomal drug transport: A molecular perspective from molecular dynamicssimulations in lipid bilayers. Advanced Drug Delivery Reviews 58, 1357-1378,doi:10.1016/j.addr.2006.09.002 (2006).101
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THESISPRESENTED ATNATIONAL GRADUATE
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As the human civilization progress
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CHAPTER - 1 SELF-HEALING POLYMERIC
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8.1.5 Atomic Force Microscopy …
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Synthetic engineering materials in
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esponse to a specific external stim
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The first work based on this approa
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een prepared from urea-formaldehyde
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monomer systems. The addition of EN
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Figure - 1.10: Self-healing process
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was required to reach healing effic
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In addition to above works, some ot
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that have been identified to be tak
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part of the chapter, these material
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Figure - 1.17: Self-healing of the
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commercialized under tradenames; Nu
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joined together at temperature high
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Inspired by these findings, the fir
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temperature greater than 80 o C in
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Figure - 1.27: Sulfur chemistry bas
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A different kind of sulfur chemistr
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Figure - 1.29: Dynamic covalent che
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cracks. The recovered droplets afte
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23 White, S. R. et al. Autonomic he
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65 Taber, D. F. & Frankowski, K. J.
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107 Kushner, A. M., Vossler, J. D.,
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148 Park, J. S., Kim, H. S. & Hahn,
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The value of subscripts “n”,
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Triethylamine (TEA) (Sigma-Aldrich
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To prepare the monolayer assembly o
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was added followed by addition of 0
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ELABORATION OF SELF-HEALING POLYMER
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ELABORATION DES MEMBRANES POLYMERES