4(%3)3 - Ecole nationale supérieure de chimie de Montpellier

In the third step of the strategy, the RAFT agent was esterified in distilled dichloromethane withPropargyl alcohol in the presence of N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride(EDC) and DMAP at 0 o C for a period of 15 hours (Figure – 5.12). After 15 hours, the reaction content wasfiltered to remove the urea formed. The red color filtrate thus obtained was concentrated and after thework up process, a deep red colored viscous liquid was obtained. The structure of esterification productwas verified with 1 HNMR (Figure – 5.13).Figure – 5.12: Synthesis of alkyne derivative of RAFT agent via esterification reactionFigure – 5.13: 1HNMR spectra obtained for Ethynyl 4-(phenylcarbonothioylthio)-4-cyano-pentanoate133