III International Conference

PP-I-38column prepared (l = 110 mm, d = 8 mm) has been used for semi-preparativeenantioseparation of PhSOMe and p-MePhSOMe (Figure 1). For these sulfoxides, thestereoselectivity factors measured in static conditions were 4.5 and 2.5, respectively, thatgives promising opportunities of dynamic preparative enantioseparation of small alkyl arylsulfoxides, provided that the separation rate is low enough to approach the sorptionequilibrium conditions.Figure 1. Separation of PhSOMe by chiral liquid chromatography with [Zn 2 BDC . (L-Lac) . DMF] as the stationary phase. Eluent: CH 2 Cl 2 with increasing amount of added DMF(stepwise, 0.1 vol.-% in the beginning and then 1.0 vol.-%).Acknowledgement. The authors thank the Russian Foundation for Basic Research for thesupport of this work, grant 06-03-32214.References1. D. N. Dybtsev, A. L. Nuzhdin, H. Chun, K. P. Bryliakov, E. P. Talsi, V. P. Fedin, K. Kim,Angew. Chem. Angew. Chem. Int. Ed. Engl. 45 (2006) 916.77