CONSCIOUSNESS

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106 2. Neuroscience linearbiomedphys.com/content/pdf/1753-4631-1-5.pdf [3] Watt RC and Hameroff SR. Phase space electroencephalography (EEG): a new mode of intraoperative EEG analysis. Int J Clin Monit Comput. 5(1): 3-13, 1988. C19 130 Anti-Aging and Neuroprotective Effect of Estradiol in Aging Female Rat Brain Pardeep Kumar, Pardeep Kumar, Asia Taha, R.K. Kale, S.M.Cowsik And Najma Zaheer Baquer (Jawaharlal Nehru University, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India) Aging in females and males is considered as the end of natural protection against age related diseases like osteoporosis, coronary heart disease, diabetes, Alzheimer’s disease and Parkinson’s disease. Most of these changes increase during menopausal condition in females when the level of estradiol is decreased. The objective of this study was to observe the changes in activities of Monoamine oxidase, Glucose transporter 4 levels, Membrane fluidity, Lipid peroxidation levels and Lipofuscin accumulation occurring in female rats of 3 months (young), 12 months (adult) and 24 months (old) age groups, and to see whether these changes are restored to normal levels after exogenous administration of estradiol (0.1 micro-gram/g body weight for one month). The results obtained in the present work revealed that normal aging was associated with significant increases in the activity of monoamine oxidase, lipid peroxidation levels and lipofuscin accumulation in brain of aging female rats but decrease in GLUT 4 level and membrane fluidity. The present study showed that Estradiol treatment significantly decreased MAO activity, lipid peroxidation and lipofuscin accumulation in brain regions of aging rats, and reversal of GLUT 4 levels and membrane fluidity. It can therefore be concluded that Estradiol’s beneficial effects seemed to arise from its antilipofuscin, antioxidant, antilipidperoxidative and thereby anti-aging actions. The results of this study will be useful for pharmacological modification of the aging process and development of new drugs for age related disorders. P8 131 Self Evidence: Cognitive Neuroscience and Consciousness as a Variable Nathan Munn (General Education, University of Montana - Helena, Helena, MT) “Self” as a construct is difficult to define. Brain imaging is implicating the precuneus and ventral medial prefrontal cortex as possible default areas of activation during self-reflection, working in concert with other brain structures such as the dorsal-lateral prefrontal cortex, the hippocampus, and limbic structures. In addition, a cohesive conscious experience corresponds to cortical EEG synchronization. Support for these data is found in literature on borderline personality disorder, dissociative identity disorder, major depression, and other psychiatric disorders. Pathological childhood development contributes to these disorders’ impaired self-image, self-identity, and self-statements. Psychotherapy is efficacious in treating these disorders of self. Taking these lines of evidence as a whole implies the self is not necessarily a stable entity but rather can be very plastic. A definition of “self” based on these data is presented, along with ramifications on consciousness per se as a variable. A detailed phenomenological/existential case report of a suicidal person is used to illustrate these findings and proposals. P2 132 Voices from the Other Side: Neuroscience, Attachment Theory and the Creative Self Carole Brooks Platt (independent scholar / Ph.D. Rice University, Bellaire, TX) Julian Jaynes originally identified the right temporal lobe’s role in the inspired voices of poets and prophets. In his Muse Factor experiment, Michael Persinger used a college questionnaire to show that a sense of alien presence was triggered by intense verbal meaningfulness, which he attributed to synchronous firing of the left and right temporal lobes. Applying the Muse Factor theory to the biography and words of great poets, religious figures and mediums, we see how male dissociative poets and mystics erect a hierarchical and self-confirming system to stabilize the self. Their female counterparts more often self-destruct. In either case,
2. Neuroscience 107 collaboration between the hemispheres and in therapeutic or creative dyads produces both presence and poetry. What was absent from Jaynes and Persinger was the role of childhood trauma in dissociation. Yet, 19th-century pioneers in psychology had already discovered the traumatic origins of dissociation. Recent scientific research is showing how genetic predisposition plus trauma cause dissociation along with observable changes in the brain. EEG and PET scans have demonstrated that distinct neural networks lie at the base of dissociative states, with differences as striking as blindness versus sight. Neuropsychologist and attachment theorist Allan Schore points to the role of the right hemisphere in developing a core sense of self through the mother-infant bond and dividing it in response to childhood trauma and later stressors. Analysts from the nineteenth through the twenty-first century have witnessed frequent paranormal claims, such as telepathy, in mediums and dissociative patients. Case studies point to the role of an empathic therapeutic matrix where unconscious transfers of information occur and imaginative constructs both heal the patient and change the therapist’s own beliefs. C20 2.8 Anesthesia 2.9 Cellular and sub-neural processes 133 The Hypersite Model of Electrofractal Consciousness and the Search for “Bright Matter” Erhard Bieberich (Institute of Molecular Medicine, Medical College of Georgia, Augusta, GA) Consciousness research has focused on defining the physiological substrate of consciousness. However, defining this substrate may not distinguish between the physiological substance generating consciousness and the substance that is conscious. While it is reasonable to assume that these substances are similar, conscious or “bright matter” must have additional features that distinguish it from a non-conscious physiological substance. Bright matter emerges as a physical substance mediating information sharing between cells and molecules. In this study, the location of consciousness will be defined as a hypersite, a biological entity that encompasses the physiological substrate of consciousness and the bright matter emerging from it. The hypersite can be formed by an ensemble of molecules within a single neuron, but may also stretch over cells such as a cortical column of neurons or a neural network. The amount of shared information will determine the spatial extension and duration of the hypersite, which will eventually become self-aware. In this study, we will discuss how information can be shared in such a way that a short-lived molecular hypersite with primitive proto-consciousness extends to an ensemble of neurons with continuous self-awareness. Instrumental to this type of information sharing is the fractal topology of bright matter and its programming by a neural network with equivalent topology. We will also discuss overlapping electron orbitals in membrane lipids and microtubules as candidate substrate for bright matter (“electrofractal consciousness”). Finally, we will discuss how bright matter can be generated in an artificial device and how its presence can be detected. C3 134 Clarifying the Qubit - Response to recent attack against Penrose-Hameroff ORCH OR Stuart Hameroff (Anesthesiology, Psychol., CCS, University of Arizona, Tucson, AZ) INTRODUCTION The Penrose-Hameroff orchestrated objective reduction (Orch OR) theory postulates quantum computation in microtubules (MTs) inside brain neurons as an explanation for consciousness. Orch OR has been attacked by McKemmish et al (Phys Rev E, 80:021912, 2009) who assert Orch OR in MTs is biologically unfeasible, and unsalvageable. BACKGROUND MTs are cylindrical lattices of peanut-shaped tubulin proteins. The basic Orch OR idea is that discrete MT tubulin states act as information bits and quantum bits (qubits) in MT computers inside brain neurons. Orch OR suggests MT tubulin qubits switch coherently and compute by entanglement with other tubulins, performing quantum computations which self-collapse by Penrose objective reduction. SPECIFIC CRITICISM OF ORCH OR McKemmish et al focus on switching between discrete tubulin bit and qubit
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TOWARD A SCIENCE OF CONSCIOUSNESS A
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3 WELCOME Welcome to the 2010 Tucso
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Olympus Corporation of America and
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7 PROGRAM OUTLINE TOWARD A SCIENCE
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Program Outline 9 THURSDAY April 15
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Program Outline 11 Evening 7:30 pm
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Program Outline 13 9:00 - 9:20 pm E
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Pre-Conference Workshops 15 9a Upda
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17 Tuesday, April 13, 2010 CONFEREN
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Program 19 C7 Hein Van Schie, Contr
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Program 21 C10 C11 C12 C13 Phenomen
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Program 23 Art & Media Installation
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Program 25 P4 Richard Blum, The Arc
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Program 27 P6 Augmentations of Cons
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Program 29 Friday, April 16 PL7 PL8
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Program 31 C20 C21 Michael Franklin
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Program 33 P8 Robert Mays, A Theory
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Program 35 P10 Ian O’Loughlin, Co
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Program 37 Herve Lambert, The Conte
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3.11 Cognitive development .. . . .
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1. Philosophy 41 conflict was prima
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1. Philosophy 43 and act. Conscious
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1. Philosophy 45 hood conscious min
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1. Philosophy 47 possess some kind
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1. Philosophy 49 undermine the robu
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1. Philosophy 51 21 Fine-Grained Su
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1. Philosophy 53 Thus, the ability
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Page 117 and 118: 2. Neuroscience 115 2.15 Specific b
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4. Physical and Biological Sciences
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5. Experiential Approaches 179 resu
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5. Experiential Approaches 181 266
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5. Experiential Approaches 183 bodi
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5. Experiential Approaches 185 othe
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5. Experiential Approaches 187 free
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5. Experiential Approaches 191 spir
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5. Experiential Approaches 193 tual
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5. Experiential Approaches 195 lepa
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5. Experiential Approaches 197 a th
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5. Experiential Approaches 199 to c
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5. Experiential Approaches 201 very
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5. Experiential Approaches 205 had
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6. Culture and the Humanities 207 T
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6. Culture and the Humanities 209 f
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6. Culture and the Humanities 211 3
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6. Culture and the Humanities 213 3
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6. Culture and the Humanities 215
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6. Culture and the Humanities 217 O
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6. Culture and the Humanities 219 t
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6. Culture and the Humanities 221 F
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6. Culture and the Humanities 223 T
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6. Culture and the Humanities 225 i
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Index to Authors 227 Jungleib S., 2
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Study consciousness at home… Two
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APRIL 12-17, 2010 TUCSON ARIZONA No
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Notes
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CONSCIOUSNESS

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