Anemia of Prematurity - Portal Neonatal

Mixed apnea accounts for approximately 50-75% of all cases of apnea in premature
neonates, 10-20% of obstructive apneas, and 10-25% of central apneas. In 50% of all
apneic episodes, central apnea is either preceded or followed by an obstructive component
and leads to mixed apnea.
• Internationally: To the author's knowledge, no data are available to compare the incidences
of AOP in other countries.
Mortality/Morbidity: Butcher-Puech and coworkers found that infants in whom obstructive apnea
exceeded 20 seconds in duration had a higher incidence of intraventricular hemorrhage,
hydrocephalus, prolonged mechanical ventilation, and abnormal neurologic development after their
first year of life. In 1985, Perlman and Volpe described a decrease in the cerebral blood flow velocity
that accompanies severe bradycardia (ie, heart rate