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Anemia of Prematurity - Portal Neonatal

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irth; symptoms may include jitteriness or seizure activity. Hypocalcemia (levels 90th percentile for gestational age or >4000 g in the term infant) occurs<br />

in 15-45% <strong>of</strong> diabetic pregnancies. When present, the infant appears puffy, fat, ruddy, and<br />

<strong>of</strong>ten mildly limp.<br />

• Impaired fetal growth, secondary to poor placental blood flow, is a consequence <strong>of</strong> severe<br />

maternal diabetics with diabetic nephropathy. Perinatal asphyxia, more common in such<br />

infants, may be anticipated by prenatal history, thus stressing the importance <strong>of</strong><br />

communication between obstetrician and pediatrician.<br />

Causes:<br />

• HbA1C levels<br />

o Complications caused by maternal hyperglycemia during pregnancy are reflected<br />

by HbA1C levels, particularly during the first trimester <strong>of</strong> pregnancy.<br />

o Because HbA1C is a direct measure <strong>of</strong> glucose control in the mother, higher levels<br />

are predictive <strong>of</strong> increased risks for congenital complications. Thus, the incidence <strong>of</strong><br />

complications has been reported as 3.4% with HbA1C levels lower than 8.5% and<br />

22.4% with levels higher than 8.5%.

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