19.12.2012 Views

Anemia of Prematurity - Portal Neonatal

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Picture 2. Determinants <strong>of</strong> oxygenation during pressure-limited time-cycled ventilation. Shaded<br />

circles represent ventilator-controlled variables. Solid lines represent the simple mathematical<br />

relationships that determine mean airway pressure and oxygenation, whereas dashed lines<br />

represent relationships that cannot be quantified in a simple mathematical way (From Carlo WA,<br />

Greenough A, Chatburn RL).<br />

Picture 3. Effects <strong>of</strong> incomplete inspiration (A) or incomplete expiration (B) on gas exchange. An<br />

incomplete inspiration leads to decreases in tidal volume and mean airway pressure. Hypercapnia<br />

and hypoxemia may result. An incomplete expiration may lead to decreases in compliance and tidal<br />

volume and an increase in mean airway pressure. Hypercapnia with a decrease in PaO2 may result.<br />

However, gas trapping and its resulting increase in mean airway pressure may decrease venous<br />

return, decreasing cardiac output and impairing oxygen delivery (From Carlo WA, Greenough A,<br />

Chatburn RL).<br />

Picture 4. Estimation <strong>of</strong> optimal inspiratory and expiratory times based on chest wall motion (From<br />

Ambalavanan N, Carlo WA)

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