Anemia of Prematurity - Portal Neonatal

Drug Name
Pediatric Dose
of acute airway obstruction
Marked improvement in oxygenation may occur within minutes, hence,
wean infant's inspired oxygen and/or ventilator pressure (expired tidal
volume) as indicated by blood gases; monitor systemic oxygenation by
pulse oxymetry to avoid hypoxia and/or hyperoxia; surfactant may
reflux into ET (hence, administer rapidly followed by positive pressure
ventilation); cyanosis, bradycardia, or changes in blood pressure have
occurred during dosing procedures; because ET rarely may become
occluded, suction infant's tube (preferably using a closed system)
before administering surfactant
Poractant (Curosurf) -- Lowers surface tension on alveolar surfaces
during respiration and stabilizes alveoli against collapse at resting
transpulmonary pressures. Indicated to treat RDS in premature infants.
For ET use only.
ET: 2.5 mL/kg (200 mg/kg); then 1.25 mL/kg (100 mg/kg) at 12-h
intervals prn in 2 subsequent doses
Contraindications Documented hypersensitivity
Interactions None reported
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions
Drug Name
Correction of acidosis, hypotension, anemia, hypoglycemia, and
hypothermia recommended before administration; marked
improvement in oxygenation may occur within minutes; monitor
systemic oxygenation to avoid hyperoxia
Colfosceril (Exosurf Neonatal) -- Lowers surface tension on alveolar
surfaces during respiration and stabilizes alveoli against collapse at
resting transpulmonary pressures. For ET use only.
Pediatric Dose ET: 5 mL/kg (67.5 mg/kg) q12h for 1-4 doses
Contraindications Documented hypersensitivity
Interactions None reported
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions
Rapidly affects oxygenation and lung compliance; only for instillation
into trachea; surfactant may reflux into ET, hence, administer rapidly
followed by ventilation; because ET rarely may become blocked,
suction ET (preferably using closed suction system) before surfactant
administration; pulmonary hemorrhage may occur in infants weighing