Anemia of Prematurity - Portal Neonatal

DIFFERENTIALS Section 4 of 9
Anemia, Acute Biliary Atresia
Cholestasis Galactosemia
Hemolytic Disease of Newborn Hypothyroidism
Jaundice, Neonatal Neonatal Sepsis
Polycythemia Polycythemia of the Newborn
Other Problems to be Considered:
Hereditary nonspherocytic anemia Spherocytosis
Acanthocytosis Ovalocytosis
Hemangiomatosis Large cephalhematoma
Dehydration Inadequate breastfeeding
G-6-PD deficiency
Lab Studies:
WORKUP Section 5 of 9
• Measure total serum bilirubin in neonates who have jaundice that has progressed from the
facies to the chest and in neonates at risk for hemolytic disease of the newborn.
• The following tests are to be considered if serum bilirubin is greater than 12 mg/dL (170
pmol/L). A total serum bilirubin rising faster than 5 mg/dL/d (85 pmol/L/d) or jaundice before 24
hours of life suggests pathologic jaundice.
• Fractionated serum bilirubin: A level of conjugated bilirubin greater than 2.0 mg/dL (34 pmol/L)
suggests cholestasis, biliary atresia, or sepsis (see Jaundice, Neonatal).
• Complete blood count
o Polycythemia (Hct >65%)
o Anemia (Hct