Anemia of Prematurity - Portal Neonatal

Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions
Drug Name
Pediatric Dose
Liver impairment, blood dyscrasias, CNS disease; inject with caution in
patients receiving corticosteroids or patients predisposed to edema
because the drug molecule contains sodium
Erythromycin (E-Mycin, Erythrocin) -- Macrolide antimicrobial agent that
is primarily bacteriostatic and is active against most gram-positive
bacteria, such as Neisseria species, Mycoplasma pneumoniae,
Ureaplasma urealyticum, and Chlamydia trachomatis. Not well
concentrated in the CSF.
1200 g: 10 mg/kg PO/IV/IM q8h
Contraindications Documented hypersensitivity; hepatic impairment
Interactions
CYP1A2 and CYP3A4 inhibitor; coadministration may increase toxicity of
theophylline, digoxin, carbamazepine, and cyclosporine; may potentiate
anticoagulant effects of warfarin
Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions
Drug Name
Pediatric Dose
Avoid parenteral administration because of associated tissue damage;
caution in liver disease; estolate formulation may cause cholestatic
jaundice; GI adverse effects are common (give doses pc); discontinue
use if nausea, vomiting, malaise, abdominal colic, or fever occur
Piperacillin (Pipracil) -- An acylampicillin with excellent activity against
Pseudomonas aeruginosa. Effective against Klebsiella pneumonia,
Proteus mirabilis, B fragilis, S marcescens, and many strains of
Enterobacter. Administer in combination with an aminoglycoside.
7 days and 1200-2000 g: 75 mg/kg IV/IM q8h
>7 days and >2000 g: 75 mg/kg/dose IV/IM q6h
Contraindications Documented hypersensitivity
Interactions
Synergic and antagonistic interactions observed when combined with
various cephalosporins; piperacillin at high concentrations may physically
inactivate aminoglycosides; coadministration with aminoglycosides has
synergistic effects
Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions Dosage modification required in patients with impaired renal function
Drug Category: Antivirals -- A viral infection, such as HSV, may masquerade as bacterial sepsis. At
the onset of the infection, treatment must be initiated promptly to effectively inhibit the replicating
virus.
Drug Name
Pediatric Dose
Acyclovir (Zovirax) -- Used for treatment of mucosal, cutaneous, and
systemic HSV-1 and HSV-2 infections.
1500 mg/m 2 /d PO/IV divided q8h or 30 mg/kg/d PO/IV divided q8h for
14-21 d; doses as high as 45-60 mg/kg/d divided q8h have been used
in full-term infants
Premature infants: 20 mg/kg/d PO/IV divided q12h for 14-21 d
Contraindications Documented hypersensitivity
Interactions
Concomitant use of probenecid or zidovudine prolongs half-life and
increases CNS toxicity of acyclovir