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Anemia of Prematurity - Portal Neonatal

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• BP in newborns depends on a variety <strong>of</strong> factors, including gestational age, postnatal age,<br />

and birth weight. Hypertension can be observed in a variety <strong>of</strong> situations in the modern<br />

NICU and is especially common in infants who have undergone umbilical arterial<br />

catheterization. A careful diagnostic evaluation should lead to determination <strong>of</strong> the<br />

underlying cause <strong>of</strong> hypertension in most infants. Tailor treatment decisions, which may<br />

include intravenous therapy, oral therapy, or both, to the severity <strong>of</strong> the hypertension.<br />

Hypertension resolves in most infants over time, although a small number <strong>of</strong> infants may<br />

have persistent BP elevation throughout childhood.<br />

Patient Education: Educate the parents <strong>of</strong> infants who develop hypertension requiring drug<br />

therapy about the expected effects and side effects <strong>of</strong> their infant's antihypertensive medications. In<br />

addition, arrange home BP monitoring equipment and educate the parents in its use prior to the<br />

infant's discharge from the NICU. Parents must monitor the BP <strong>of</strong> all infants discharged on<br />

antihypertensive medications on a regular basis (ie, usually daily); parents should call the physician<br />

if the infant's BP exceeds or falls below the target range.<br />

MISCELLANEOUS Section 9 <strong>of</strong> 10<br />

Medical/Legal Pitfalls: Failure to diagnose or treat neonatal hypertension; major concern would be<br />

missing an underlying cause <strong>of</strong> hypertension such as renal disease that might require specific<br />

therapy.<br />

BIBLIOGRAPHY Section 10 <strong>of</strong> 10<br />

• Abman SH, Warady BA, Lum GM: Systemic hypertension in infants with bronchopulmonary<br />

dysplasia. J Pediatr 1984 Jun; 104(6): 928-31[Medline].<br />

• Adelman RD: Long-term follow-up <strong>of</strong> neonatal renovascular hypertension. Pediatr Nephrol<br />

1987 Jan; 1(1): 35-41[Medline].<br />

• Alagappan A, Malloy MH: Systemic hypertension in very low-birth weight infants with<br />

bronchopulmonary dysplasia: incidence and risk factors. Am J Perinatol 1998 Jan; 15(1): 3-<br />

8[Medline].<br />

• Boedy RF, Goldberg AK, Howell CG Jr: Incidence <strong>of</strong> hypertension in infants on<br />

extracorporeal membrane oxygenation. J Pediatr Surg 1990 Feb; 25(2): 258-61[Medline].<br />

• Chandar JJ, Sfakianakis GN, Zilleruelo GE: ACE inhibition scintigraphy in the management<br />

<strong>of</strong> hypertension in children. Pediatric Nephrology 1999; 13: 493-500[Medline].<br />

• Crapanzano MS, Strong WB, Newman IR: Calf blood pressure: clinical implications and<br />

correlations with arm blood pressure in infants and young children. Pediatrics 1996 Feb;<br />

97(2): 220-4[Medline].<br />

• de Swiet M, Fayers P, Shinebourne EA: Systolic blood pressure in a population <strong>of</strong> infants in<br />

the first year <strong>of</strong> life: the Brompton study. Pediatrics 1980 May; 65(5): 1028-35[Medline].<br />

• Duley L: Pre-eclampsia and the hypertensive disorders <strong>of</strong> pregnancy. Br Med Bull 2003;<br />

67(1): 161-76[Medline].<br />

• Elliot SJ, Hansen TN: <strong>Neonatal</strong> hypertension. In: Long WA, ed. Fetal and <strong>Neonatal</strong><br />

Cardiology. Philadelphia, Pa: WB Saunders Co; 1990:492-498.

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