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Anemia of Prematurity - Portal Neonatal

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Intrathoracic tumors or masses<br />

Table 5. Tumor or Mass Causes<br />

o Pericardial teratoma<br />

o Rhabdomyoma<br />

o Mediastinal teratoma<br />

o Cervical vascular hamartoma<br />

o Pulmonary fibrosarcoma<br />

o Leiomyosarcoma<br />

o Pulmonary mesenchymal malformation<br />

o Lymphangiectasia<br />

o Bronchopulmonary sequestration<br />

o Cystic adenomatoid malformation <strong>of</strong> the lung<br />

o Upper airway atresia or obstruction (laryngeal or tracheal)<br />

o Diaphragmatic hernia<br />

Abdominal tumors or masses<br />

o Metabolic nephroma<br />

o Polycystic kidneys<br />

o Neuroblastoma<br />

o Hepatic mesenchymal hamartoma<br />

o Hepatoblastoma<br />

o Ovarian cysts<br />

Other conditions<br />

o Placental choriocarcinoma<br />

o Placental chorangioma<br />

o Cystic hygroma<br />

o Intussusception<br />

o Meconium peritonitis<br />

o Intracranial teratoma<br />

o Sacrococcygeal teratoma<br />

• Venous return is directly impaired by such conditions as pericardial teratomas and cardiac<br />

rhabdomyosarcomas. Upper airway (laryngeal, tracheal) atresia or obstruction leads to<br />

massive pulmonary overdistention and, thus, to impaired cardiac filling. Cystic hygromas<br />

(see Table 5) are mentioned again since they comprise an important and common example<br />

<strong>of</strong> mass compression with obstruction <strong>of</strong> venous-lymphatic return. Meconium peritonitis is<br />

noted in Table 5 and in Table 3. This redundancy is excused by the fact that some<br />

observers have postulated an association with hydrops on the basis <strong>of</strong> mass effects on<br />

venous return; as noted earlier, the association is almost certainly one with fetal infection<br />

and consequent red cell aplasia.<br />

o Some <strong>of</strong> these conditions may lead to fetal hydrops not because <strong>of</strong> mass<br />

compression effects but because their intense vascularization may lead to<br />

arteriovenous shunting and/or to massive fetal hemorrhage. Such consequences<br />

are especially common with sacrococcygeal teratomas and with placental<br />

chorioangiomas. In both instances, fetal high-output cardiac failure ultimately may<br />

lead to fetal hydrops and/or death. Sacrococcygeal teratoma is associated with<br />

hydrops in one fifth to one third <strong>of</strong> cases in several case series; fetal coagulopathy,

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