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Anemia of Prematurity - Portal Neonatal

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duodenal atresia, the obstruction lies distal to the ampulla or is incomplete. In these situations,<br />

vomiting is bilious. The abdomen is usually distended by the dilated duodenal loop but may be<br />

scaphoid if the obstruction is incomplete. Preoperative treatment for these patients includes fluid<br />

resuscitation and nasogastric decompression.<br />

Consultation with a cardiologist and echocardiography may be helpful because <strong>of</strong> the high incidence<br />

<strong>of</strong> associated anomalies. If the obstruction is incomplete as evidenced by some distal gas on plain<br />

radiography, urgent laparotomy may be necessary to differentiate duodenal atresia from malrotation<br />

with volvulus. Surgery involves resection or bypass <strong>of</strong> the atretic segment. A web must be identified<br />

and completely resected to the degree that it no longer obstructs the distal lumen.<br />

Many pediatric surgeons bypass rather than resect the atretic segment to avoid injury to the ampulla<br />

or to the pancreatic blood supply that usually is nearby. A severely dilated duodenum may require a<br />

tapering duodenoplasty to mitigate the poor long-term duodenal motility that can be observed in these<br />

dilated proximal segments. A nasoenteric feeding tube is <strong>of</strong>ten placed across the duodenal<br />

anastomosis for early decompression and late feeding.<br />

Jejunoileal atresia<br />

Atresia <strong>of</strong> the jejunum or ileum is more common than duodenal atresia, occurring in 1 in 1500 births.<br />

Small-bowel obstruction from jejunoileal atresia may also lead to polyhydramnios. Premature delivery<br />

is observed in one third <strong>of</strong> patients with intestinal atresia.<br />

In contrast to duodenal atresia, jejunoileal atresia is widely considered to be a condition acquired<br />

during development, rather than a preprogrammed anomaly. In classic work on fetal dogs in 1955,<br />

Louw and Barnard demonstrated the pathophysiology by which intrauterine mesenteric vascular<br />

accidents produce atresia in the segment <strong>of</strong> intestine that is devascularized. The extent <strong>of</strong> atresia and<br />

the appearance <strong>of</strong> the atretic intestinal segment vary according to the timing and degree <strong>of</strong> the<br />

disruption <strong>of</strong> the mesenteric blood supply. Atresias may be focal or multiple throughout the small<br />

bowel. Interruption <strong>of</strong> the main superior mesenteric blood supply can result in atresia <strong>of</strong> most <strong>of</strong> the<br />

jejunum and ileum. Other abdominal conditions, such as gastroschisis or intrauterine intussusception,<br />

may be associated with intestinal atresia, presumably from kinking, stretching, or otherwise disrupting<br />

the blood supply to the fetal bowel. Chromosomal anomalies are rare (

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