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Special cases:
n refractory CTAM: doxepin (5 mg/mL oral rinse q4–6h)
MUCOSITIS NOT ASSOCIATED WITH CANCER
First line:
n amlexanox (5% topical paste, applied in 100 mg dose QID)
n steroid (e.g. clobetasol propionate 0.05% applied 1:1 with dental
paste BID)
Reasonable: sucralfate oral rinse (5–10 mL suspension, equal to 500–1000 mg,
with 2–3 min rinse QID)
Pregnancy: sucralfate oral rinse (5–10 mL suspension, equal to 500–1000 mg,
with 2–3 min rinse QID)
Pediatric:
n sucralfate oral rinse (5 mL suspension, equal to 500 mg, with 2–3 min
rinse QID)
n steroid (e.g. clobetasol propionate 0.05% applied 1:1 with dental
paste BID)
References
Mucositis and stomatitis 259
1. Coda BA, O’Sullivan B, Donaldson G, et al. Comparative efficacy of patientcontrolled
administration of morphine, hydromorphone, or sufentanil for the
treatment of oral mucositis pain following bone marrow transplantation. Pain.
1997;72(3):333–346.
2. Clarkson JE, Worthington HV, Eden OB. Interventions for treating oral mucositis
for patients with cancer receiving treatment. Cochrane Database Syst Rev.
2007(2):CD001973.
3. Collins JJ, Geake J, Grier HE, et al. Patient-controlled analgesia for mucositis
pain in children: a three-period crossover study comparing morphine and
hydromorphone. J Pediatr. 1996;129(5):722–728.
4. Dunbar PJ, Chapman CR, Buckley FP, et al. Clinical analgesic equivalence for
morphine and hydromorphone with prolonged PCA. Pain.1996;68(2–3):265–270.