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Pregnancy: morphine (initial dose 4–6 mg IV, then titrate)
Pediatric: morphine (initial dose 0.05–0.1 mg/kg IV, then titrate)
Special cases:
n Oral therapy appropriate: oxycodone or hydrocodone (5–10 mg PO
q4–6 h)
n Opioids to be avoided, low likelihood of operative intervention: ketorolac
(15–30 mg IV q6 h)
n Concern for hemodynamics or need for close titration: fentanyl (initial dose
50–100 μg IV, then titrate)
n Suspected biliary tract pain with Oddi sphincter concern: buprenorphine
(initial dose 0.3 mg IV, then titrate)
References
Undifferentiated abdominal pain 395
1. Nissman SA, Kaplan LJ, Mann BD. Critically reappraising the literature-driven
practice of analgesia administration for acute abdominal pain in the emergency
room prior to surgical evaluation. Am J Surg. 2003;185:291–296.
2. Ranji SR, Goldman LE, Simel DL, et al. Do opiates affect the clinical evaluation
of patients with acute abdominal pain? JAMA. 2006;296:1764–1774.
3. Gallagher EJ, Esses D, Lee C, et al. Randomized clinical trial of morphine in
acute abdominal pain. Ann Emerg Med. 2006;48:150–160.
4. Thomas SH, Silen W. Effect on diagnostic efficiency of analgesia for undifferentiated
abdominal pain. Br J Surg. 2003;90:5–9.
5. Klein-Kremer A, Goldman RD. Opioid administration for acute abdominal pain
in the pediatric emergency department. J Opioid Manag. 2007;3:11–14.
6. Thomas S, Silen W, Cheema F. Effects of morphine analgesia on diagnostic
accuracy in emergency department patients with abdominal pain: a prospective,
randomized trial. J Am Coll Surg. 2003;196:18–31.
7. Nelson B, Senecal E, Hong C, et al. Opioid analgesia and assessment of the
sonographic Murphy’s sign. J Emerg Med. 2005;28:409–413.
8. Bailey B, Bergeron S, Gravel J, et al. Efficacy and impact of intravenous morphine
before surgical consultation in children with right lower quadrant pain
suggestive of appendicitis: a randomized controlled trial. Ann Emerg Med.
2007;50:371–378.