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Pediatrics:<br />

n 5% lidocaine patch (1–3 patches, applied up to 12 h/day)<br />

n capsaicin cream (0.025% applied 4–5 times daily)<br />

Special case:<br />

n patient failing above approaches: nortriptyline (10–25 mg PO QHS),<br />

opioids (e.g. extended-release oxycodone 10 mg PO BID)<br />

References<br />

Post-herpetic neuralgia 357<br />

1. Kanazi GE, Johnson RW, Dworkin RH. Treatment of postherpetic neuralgia:<br />

an update. Drugs. 2000;59(5):1113–1126.<br />

2. Attal N, Cruccu G, Haanpaa M, et al. EFNS guidelines on pharmacological<br />

treatment of neuropathic pain. Eur J Neurol. 2006;13(11):1153–1169.<br />

3. Kost RG, Straus SE. Postherpetic neuralgia: pathogenesis, treatment, and<br />

prevention. N Engl J Med. 1996;335(1):32–42.<br />

4. Collins SL, Moore RA, McQuay HJ, et al. Antidepressants and anticonvulsants<br />

for diabetic neuropathy and postherpetic neuralgia: a quantitative systematic<br />

review. J Pain Symptom Manage. 2000;20(6):449–458.<br />

5. Watson CP, Vernich L, Chipman M, et al. Nortriptyline versus amitriptyline<br />

in postherpetic neuralgia: a randomized trial. Neurology. 1998;51<br />

(4):1166–1171.<br />

6. Rice AS, Maton S. Gabapentin in postherpetic neuralgia: a randomised,<br />

double blind, placebo controlled study. Pain. 2001;94(2):215–224.<br />

7. Chandra K, Shafiq N, Pandhi P, et al. Gabapentin versus nortriptyline in postherpetic<br />

neuralgia patients: a randomized, double-blind clinical trial – the<br />

GONIP Trial. <strong>Int</strong> J Clin Pharmacol Ther. 2006;44(8):358–363.<br />

8. Dworkin RH, Corbin AE, Young JP, Jr., et al. Pregabalin for the treatment of<br />

postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology.<br />

2003;60(8):1274–1283.<br />

9. Sabatowski R, Galvez R, Cherry DA, et al. Pregabalin reduces pain and<br />

improves sleep and mood disturbances in patients with post-herpetic neuralgia:<br />

results of a randomised, placebo-controlled clinical trial. Pain. 2004;109<br />

(1–2):26–35.<br />

10. Watson CP, Babul N. Efficacy of oxycodone in neuropathic pain: a randomized<br />

trial in postherpetic neuralgia. Neurology. 1998;50(6):1837–1841.

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