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Het volume van chirurgische ingrepen en de impact ervan op ... - KCE

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<strong>KCE</strong> Reports 113 Volume Outcome 87<br />

5.4.5 Definition of outcomes<br />

5.4.5.1 Mortality<br />

Table 5.40 shows that in-hospital and approximate 30-day mortality is 5.6% after colon<br />

cancer surgery (148 <strong>de</strong>aths). Mortality 1 year after surgery is 18.0%. After 2 years it is<br />

28.2%. Mean survival time (median not <strong>de</strong>fined) was 27 months (not visible in Table<br />

5.40).<br />

Table 5.40 also shows that 2-year mortality after surgery is higher with pati<strong>en</strong>ts<br />

diagnosed with a cancer of the rectosigmoid junction (4310%) in comparison with<br />

pati<strong>en</strong>ts suffering from a colon cancer (27.4%). These differ<strong>en</strong>ces confirm the necessity<br />

to add the principal diagnosis to the risk adjustm<strong>en</strong>t.<br />

Table 5.40: Colon Cancer surgery: Mortality results<br />

Number Number % Survival<br />

<strong>de</strong>aths <strong>de</strong>aths<br />

In-hospital and approximate 30-day mortality 2658 148 5.57<br />

1-year mortality 2658 479 18.02 81.98<br />

2-year mortality<br />

2-year mortality in function of principal diagnosis:<br />

2658 750 28.22 71.78<br />

153 Malignant ne<strong>op</strong>lasm of colon 2521 691 27.41 72.59<br />

1540 Malignant ne<strong>op</strong>lasm of rectosigmoid<br />

junction<br />

137 59 43.07 56.93<br />

Figure 5.18 shows how survival improves with <strong>de</strong>creasing disease stage. Pati<strong>en</strong>ts with<br />

stage 3 and 4 disease have the worst survival curves while stage 1 and 2 pati<strong>en</strong>ts have<br />

the best survival. Pati<strong>en</strong>ts with unknown disease stage are in betwe<strong>en</strong> these two groups.<br />

Figure 5.18: Colon cancer surgery: Survival curve by stage<br />

X means stage missing.<br />

Because of lack of reliable data on complications, all analyses on the <strong>volume</strong>-outcome<br />

association are limited to 2-year mortality rate. This implies that additional outcome<br />

measures such as post<strong>op</strong>erative rate of stoma, infection and anastomotic leakage, which<br />

are listed in Table 2.1 (page 16), are not analyzed in this report.

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