- Page 1: GENES ON CHROMOSOME 22 INVOLVED IN
- Page 4 and 5: PROMOTmCOMMIssm Promotor: Prof. Dr.
- Page 6 and 7: Contents List of abbreviations 9 Ch
- Page 9: List of abbreviations APC bp DCC FA
- Page 14 and 15: 2 Oncogenes and tumor suppressor ge
- Page 16 and 17: particular (parts ot) chromosomes i
- Page 18 and 19: 3 Moleculm' cloning and fUllction o
- Page 20 and 21: with wild-type (wI) p53 proved the
- Page 22 and 23: transcriptional modulator. p53 can
- Page 24 and 25: loss of markers on the long arm of
- Page 26 and 27: found in association with the hered
- Page 28 and 29: human papillary thyroid carcinomas
- Page 30 and 31: ole in mediating interactions betwe
- Page 32 and 33: 2) as part of the hereditary syndro
- Page 34 and 35: grades can be distinguished using t
- Page 36 and 37: .3 '" #22 Figure J. Localization of
- Page 38 and 39: 4.7 Other tumors with loss or I'ear
- Page 40 and 41: 5 Scope of the thesis Cytogenetic a
- Page 42 and 43: Bookstein R, Shew JY, Chen PL, Scul
- Page 44 and 45: Ewen ME, Sluss HK, Sherr CJ, Matsus
- Page 46 and 47: Joslyn G, Carlson M, Thlivris A, Al
- Page 48 and 49: Matlashewski at Lamb P, Pim D, Peac
- Page 50 and 51: inding to the retinoblastoma gene p
- Page 52 and 53: Vogelstein B, Fearon ER, Kern SC, H
- Page 55 and 56: SHORT COMMUNICATION Isolation and C
- Page 57: SHORT COMMUNICATION ACKNOWLEDG~IENT
- Page 61 and 62:
Nuefeic Adds Research, Vol. 19, No.
- Page 63:
Nucleic Acids Research, Vol, 19, No
- Page 67 and 68:
Cytogenetic, Molecular Genetic and
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abnormalities, histopathological an
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D22S193, D22Sn, D22S56 and NF2 were
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(71 %) of the 93 meningiomas comple
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#22 status No. Sex/Age (y,) Site of
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#22 status No. SexlAge (yr) Site of
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#22 status No. Sex/Age (yr) Site of
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Table 3. Summary of chromosomal fin
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No. Days in Karyotypes and/or clona
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No. Days in Karyotypes and/or clona
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112 12.1 122 123 1).1 132 133 .. '
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abnormalities were found, whereas i
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Discussion This series of meningiom
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finding that the majority of grade
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Dumanski JP, Roule~lU GA, Nordenskj
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Zucman J, Delattre 0, Desmaze C, Pl
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100
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observed in 12 out of 30 analysed e
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A B c Figure 2. Cerebral scans. A.
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Genetic analysis Fresh tumor tissue
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chromosome 22 in a major percentage
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110
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Lekanne Deprez et al. matosis 2 (NF
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Lekanne Deprez et a!. Figure I Basi
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Lekanne Deprez et al. A S ""'~"' n
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Lekanne Deprez et aL beling DNA res
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120
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Introduction Meningiomas are primar
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Hybrid cell lines, The somatic cell
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6A (data not shown), These data sug
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Isolation and characterization of t
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probably caused by the less efficie
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A 1 2 3 4 5 6 7 8 kb 9.5 7.5 4.4 2.
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cDNA sequence analysis Sequence ana
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Discussion Characterization of the
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involve loss of both the MNl and th
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D, van der Kwast TH, Zwarthoff BC (
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142
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144
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CHROMOSOME 11 ABERRATIONS ebellopon
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E BP E HP E XO D B Control: I I II
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150
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152
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NF2 Mut.nions and Meningiomas vatin
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NF2 Mutations and Meningiomas A D B
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NF2 Mutations and Meningiomas Table
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NF2 Mutations and Meningiomas Natio
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chromosomal abnormalities and tumor
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expression of the MNI gene in one o
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166
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wijzen, die rnogelijk voor rneninge
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170
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172
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1) Lekanne Deprez RH, Groen NA, Lou
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het onderzoek onontbeerlijk was. Be