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GENES ON CHROMOSOME 22 INVOLVED IN THE PATHOGENESIS OF CENTRAL NERVOUS SYSTEM TUMORS GENEN, GELEGEN OP CHROMOSOOM 22, DIE BETROKKEN ZIJN BIJ DE PATHOGENESE VAN TUMOREN VAN HET CENTRALE ZENUWSTELSEL PROEFSCRRIFT TER VERKRIJGING VAN DE GRAAD VAN DOCTOR AAN DE ERASMUS UNIVERSITEIT ROTTERDAM OP GEZAG V AN DE RECTOR MAGNIFICUS PROF. DR. P.W.C. AKKERMANS M. LIT. EN VOLGENS BESLUIT V AN RET COLLEGE V AN DEKANEN. DE OPENBARE VERDEDIGING ZAL PLAATSVINDEN OP WOENSDAG 2 NOVEMBER 1994 OM 11.45 UUR DOOR RONALD RENDRIKUS LEKANNE DIT DEPREZ GEBOREN TE OEGSTGEEST
Page 1: GENES ON CHROMOSOME 22 INVOLVED IN
Page 5 and 6: Eell ovenvillnillg lVordt Iliet ill
Page 7: Chapter II Isolation and characteri
Page 11: Chapter I General introduction 11
Page 14 and 15: 2 Oncogenes and tumor suppressor ge
Page 16 and 17: particular (parts ot) chromosomes i
Page 18 and 19: 3 Moleculm' cloning and fUllction o
Page 20 and 21: with wild-type (wI) p53 proved the
Page 22 and 23: transcriptional modulator. p53 can
Page 24 and 25: loss of markers on the long arm of
Page 26 and 27: found in association with the hered
Page 28 and 29: human papillary thyroid carcinomas
Page 30 and 31: ole in mediating interactions betwe
Page 32 and 33: 2) as part of the hereditary syndro
Page 34 and 35: grades can be distinguished using t
Page 36 and 37: .3 '" #22 Figure J. Localization of
Page 38 and 39: 4.7 Other tumors with loss or I'ear
Page 40 and 41: 5 Scope of the thesis Cytogenetic a
Page 42 and 43: Bookstein R, Shew JY, Chen PL, Scul
Page 44 and 45: Ewen ME, Sluss HK, Sherr CJ, Matsus
Page 46 and 47: Joslyn G, Carlson M, Thlivris A, Al
Page 48 and 49: Matlashewski at Lamb P, Pim D, Peac
Page 50 and 51: inding to the retinoblastoma gene p
Page 52 and 53:
Vogelstein B, Fearon ER, Kern SC, H
Page 55 and 56:
SHORT COMMUNICATION Isolation and C
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SHORT COMMUNICATION ACKNOWLEDG~IENT
Page 61 and 62:
Nuefeic Adds Research, Vol. 19, No.
Page 63:
Nucleic Acids Research, Vol, 19, No
Page 67 and 68:
Cytogenetic, Molecular Genetic and
Page 69 and 70:
abnormalities, histopathological an
Page 71 and 72:
D22S193, D22Sn, D22S56 and NF2 were
Page 73 and 74:
(71 %) of the 93 meningiomas comple
Page 75 and 76:
#22 status No. Sex/Age (y,) Site of
Page 77 and 78:
#22 status No. SexlAge (yr) Site of
Page 79 and 80:
#22 status No. Sex/Age (yr) Site of
Page 81 and 82:
Table 3. Summary of chromosomal fin
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No. Days in Karyotypes and/or clona
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No. Days in Karyotypes and/or clona
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112 12.1 122 123 1).1 132 133 .. '
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abnormalities were found, whereas i
Page 91 and 92:
Discussion This series of meningiom
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finding that the majority of grade
Page 95 and 96:
Dumanski JP, Roule~lU GA, Nordenskj
Page 97:
Zucman J, Delattre 0, Desmaze C, Pl
Page 100 and 101:
100
Page 102 and 103:
observed in 12 out of 30 analysed e
Page 104 and 105:
A B c Figure 2. Cerebral scans. A.
Page 106 and 107:
Genetic analysis Fresh tumor tissue
Page 108 and 109:
chromosome 22 in a major percentage
Page 110 and 111:
110
Page 112 and 113:
Lekanne Deprez et al. matosis 2 (NF
Page 114 and 115:
Lekanne Deprez et a!. Figure I Basi
Page 116 and 117:
Lekanne Deprez et al. A S ""'~"' n
Page 118 and 119:
Lekanne Deprez et aL beling DNA res
Page 120 and 121:
120
Page 122 and 123:
Introduction Meningiomas are primar
Page 124 and 125:
Hybrid cell lines, The somatic cell
Page 126 and 127:
6A (data not shown), These data sug
Page 128 and 129:
Isolation and characterization of t
Page 130 and 131:
probably caused by the less efficie
Page 132 and 133:
A 1 2 3 4 5 6 7 8 kb 9.5 7.5 4.4 2.
Page 134 and 135:
cDNA sequence analysis Sequence ana
Page 136 and 137:
Discussion Characterization of the
Page 138 and 139:
involve loss of both the MNl and th
Page 140 and 141:
D, van der Kwast TH, Zwarthoff BC (
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142
Page 144 and 145:
144
Page 146 and 147:
CHROMOSOME 11 ABERRATIONS ebellopon
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E BP E HP E XO D B Control: I I II
Page 150 and 151:
150
Page 152 and 153:
152
Page 154 and 155:
NF2 Mut.nions and Meningiomas vatin
Page 156 and 157:
NF2 Mutations and Meningiomas A D B
Page 158 and 159:
NF2 Mutations and Meningiomas Table
Page 160 and 161:
NF2 Mutations and Meningiomas Natio
Page 162 and 163:
chromosomal abnormalities and tumor
Page 164 and 165:
expression of the MNI gene in one o
Page 166 and 167:
166
Page 168 and 169:
wijzen, die rnogelijk voor rneninge
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170
Page 172 and 173:
172
Page 174 and 175:
1) Lekanne Deprez RH, Groen NA, Lou
Page 176:
het onderzoek onontbeerlijk was. Be
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