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Acknowledgements This study was supported by a grant from the Dutch Cancer Foundation (EUR 89-06). Support of the E.C. Biomed I Concerted Action: Molecular cytogenetics of solid tumors to E.v.D. is acknowledged. References AI Saadi A, Latimer F, Madercic M, Robbins T (1987) Cytogenetic studies of human brain tumors and their clinical significance. Cancer Genet Cylogenet 26: 127-141. Amoldus EPJ. NoorJermeer lA, Boudewijn Peters AC. Voormolen JHC, Bots GTAM, Raap AK, van Jer Ploeg M (1991) Tnlerphase cytogenetics of brain hlmors. Genes Chrom Cancer 3: 101-107. Barker G, Schafer M, White R (1984) Restriction sites containing CpG show a higher frequency of polymorphism in human DNA. Cell 36: 131-138. Diegel JA, Parmiter AH, Sutton LN, Rorke LB, Emanuel BS (1994) Abnormalities of chromosome 22 in pediatric meningiomas, Genes Chrom Cancer 9:81-87. van Biezen NA, Lekanne Deprez RH, Thijs A, Heutink P, Ooslra BA, Geurts van Kessel AHM, ZwarthoffEC (1993) Tsolation and characterization of25 unique DNA markers for human chromosome 22. Genomics 15:206- 208. Budarf ML, McDermid HE, Sellinger D, Emanuel DS (1991) Isolation and regional localization of 35 unique anonymous DNA markers for human chromosome 22, Genomics 10,996-1002. Bulli G, Assielli R, Casalone R, Paoletti P (1989) Multiple meningiomas: A clinical, surgical and cytogenetic analysis. Surg Neuml 31 :255·260. Casalone R. Granata P, Simi P, Tarantino E, Butti G, Buonaguidi R, Faggionato F, Knerich R, Solero L (1987) Recessive cancer genes in meningiomas? An analysis of 31 cases, Cancer Genet Cytogenet 27: 145-159. Casal one R, Simi P, Granata P, Minelli E, Giudici A, Butti G, Solem CL (1990) Correlation between cytogenetic and histopathological findings in 65 human meningiomas, Cancer Genet Cytogenet 45:237-243. Damhuis RAM, Mol CAM, Hoekman- van der Male (1993) Frequentie en behandeling van kanker, lKR-Regio 1988-1991: pp 10. Delleman JW, de Jong JGY, Bleeker GM (1978) Meningiomas in five members of a family over two generations, in one member simultaneously with acoustic neurinomas. Neural 28:567-570. Domenicucci M. Santoro A, D'Osvaldo DB, Delfini R, Cantore GP, Guidetti B (1989) Multiple intracranial meningiomas. J Neurosurg 70:41-44. Doney MK, Houseal TW, Soukup SW, Rutter JL, GuselJa JF, Schneider BF, Golden WL et a!. (1993) Identification of a putative tumor suppressor locus in 14q24-32 that is involved in formation and progression of meningiomas. Am J Bum Genet 53:293. 94
Dumanski JP, Roule~lU GA, Nordenskj6ld M, Collins VP (1990) Molecular genetic analysis of chromosome 22 in 81 cases of meningioma. Cancer Res 50:5863-5867. Goyns MH, Young BD, Geurts van Kessel A, de Klein A, Grosveld G, Bartram CR, Boolsma D (1984) Regional mapping of the human immunoglobulin lambda light chain to the philadelphia chromosome in chronic myeloid leukaemia. Leukemia Res 8:547-553. Hotter MH, Breuning MH, Bakker P, van Ommen GJB, Pearson PL (1985) An anonymous single copy chromosome 22 clone, D22SIO (22Cl-18), identifies an RFLP with Pstl. Nucleic Acids Res 13:7167. ISCN (1991) Mitelman F (ed): Guidelines for Cancer Cytogenetics, Supplement to an Intemational System for Human Cytogenetic Nomenclature. Basel: S. Karger. JiiaskeUiinen J, Haltia M. Laasonen E. Wahlstrom T, Vallonen S (1985) The growth rate of intracranial meningiomas and its relation to histlogy. Surg NeufoI24:165-172. de Jong PJ, Yokohata K. Chen C, Lohman F, Pederson L, McNinch J, van Oilla M (1989) Human chromosome-specific partial digest libraries in k and cos mid vectors. Cytogenet Cell Genet 51 :985. Katsuyama J. Papenhallsen PR, Herz F, Gazivoda P, Hirano A, Koss LG (1986) Chromosome abnormalities in meningiomas. Cancer Genet Cytogenet 22:63-68. Kepes JJ (1982) Meningiomas, Biology, Pathology, Oifferentiill ~iagnosis, New York:Masson. Koper JW, Foekens JA, Braakman R, Lamberts SWJ (1990) Effects of progesterone on the response to epidermal growth factor and other growth factors in cultured human meningioma cells. Cancer Res 50:2604- 260). Lekanne Deprez RH, Groen NA, van Bielen NA, Hagemeijer A, van Dronen E, Koper JW, Avezaat CJJ, Bootsma D, Zwarthoff EC (1991a) A t(4;22) in a meningioma points to the localization of a putative tUmorsuppressor gene. Am J Hum Genet 48:783-790. Lekanne Deprez RH, van Biezen NA, Heutink P, BoejhHrat KRGS, de Klein A, Geurts van Kessel AHM, ZwarthoffEC (l99Ib) A new polymorphic probe on chromosome 22: NBI7 (D22SI81). A new polymorphic probe on chromosome 22: NB35 (022SI82). A new polymorphic probe on chromosome 22; NB84 (022S183). A new polymorphic probe on chromosome 22q: NBI29 (022S193). Nucleic Acids Res 19:686-687, Lekanne Deprez RH, van Biezen NA, Breedveld GJ, Boejharat KRGS, de Klein A. Geurts van Kessel AHM, Zwarthoff EC (1991e) A new polymorphic probe on chromosome 22: NBS (022S201), Nucleic Acids Res, 19:1963. Lekanne Deprez RH, Groen NA, Louz 0, Hagemeijer A, vall Drunen E, Koper JW, Avezaat CJJ, Bootsma D, van der Kwast TH, Zwarlhofr EC (1994) Constitutional DNA-level aberrations in chromosome 22 in a patient with multiple meningiomas. Genes Chrom Cancer 9: 124-128. Lekanne Deprez RH, Bianchi AB, Groen NA, Seizinger BR, Hagemeijer A, van Drunen E, Bootsma D, Koper JW, Avezaat CJJ, Kley N, Zwarthoff EC. Frequent NF2 gene transcript mutations in sporadic meningiomas and vestibular schwannomas. Am J Hum Genet (in pres~). Logan JA, Seizinger BR, Atkins L, Martuza RL (1990) Loss of the Y chromosome in meningiomas, Cancer Gene! Cytogenet 45:41-47. Maltby EL, Ironside JW, Battersby RDE (1988) Cytogenetic studies in 50 meningiomas, Cancer Genet Cytogenet 31:199-210. 95
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GENES ON CHROMOSOME 22 INVOLVED IN
Page 4 and 5:
PROMOTmCOMMIssm Promotor: Prof. Dr.
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Contents List of abbreviations 9 Ch
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List of abbreviations APC bp DCC FA
Page 13 and 14:
1 Cancer is a genetic disease It is
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transformation came from somatic ce
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to tumorigenesis if a mutation inac
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is that this interaction inactivate
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endogenous wt p53 by forming mixed
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Recent studies in these families ha
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In about 15% of all colon tumors an
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e explained by assuming that the nu
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3.6 The NFl gene Neurofibromatosis
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4 MENINGIOMA 4.1 Cells of origin In
Page 33 and 34:
fossa and foramen magnum), convexit
Page 35 and 36:
early cell cultures the presence of
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gene (Dumanski et aI., NNFF consort
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et aI., 1991b; Larsson et aI., 1990
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6 References Aaltonen LA, Peltomiik
Page 43 and 44: (1988) SV40 large tumor antigen for
Page 45 and 46: Haber DA, Buckler AJ, Glaser T, Cal
Page 47 and 48: carcinomas. Genes Chrom Cancer 2:19
Page 49 and 50: Pelletier J, Breunin~ W, Kashtan CE
Page 51 and 52: Stratton MR, Darling J, Lantos PL,
Page 53: Chapter II Isolatioll alld characte
Page 56 and 57: SHORT COMMUNICATION TABLE 1 Charact
Page 59: Appendix A lIew polymorphic probe 0
Page 62 and 63: Nudeic Acids Research, Vol. 19, No.
Page 65: Chapter III Cytogenetic, molecular
Page 68 and 69: Introduction Meningiomas are consid
Page 70 and 71: defined by evaluating 6 histologica
Page 72 and 73: number of clonal chromosomal abnorm
Page 74 and 75: #22 status No. Sex/Age (yr) Site of
Page 76 and 77: #22 slattls No. SexiAge (yr) Site o
Page 78 and 79: #22 status No. Sex/Age (yr) Site of
Page 80 and 81: Table 2. Comparison of FISH, cytoge
Page 82 and 83: No. Days in Karyotypes andlor clona
Page 84 and 85: No. Days in Karyotypes and/or clona
Page 86 and 87: to map both breakpoints (data not s
Page 88 and 89: Statistical analyses concerning age
Page 90 and 91: Tuble 4. Frequency tables between d
Page 92 and 93: from adult patients, indicating tha
Page 96 and 97: McDermid HE, Duncan AMV, Higgins MJ
Page 99 and 100: Chapter IV Familial anaplastic epen
Page 101 and 102: Familial anaplastic ependymoma: evi
Page 103 and 104: PATIENT A, born 1977, presented at
Page 105 and 106: Microscopic examination (patients A
Page 107 and 108: (Lekanne Deprez et aI., 1994). Tabl
Page 109 and 110: Chapter V A t(4;22) ill a meningiom
Page 111 and 112: Am. J. HI/m. Genet. 48:783-790, 199
Page 113 and 114: Putative Tumor-suppressor Gene in M
Page 119 and 120: Chapter VI Molecular clolling of a
Page 121 and 122: Molecular Cloning of a Gene Disrupt
Page 123 and 124: to playa role in the development of
Page 125 and 126: total sheared human genomic DNA bef
Page 127 and 128: Genomic cosmid contig spanning the
Page 129 and 130: probe A is conserved in hamster DNA
Page 131 and 132: Southerll, 1l0l1hern blots and evol
Page 133 and 134: The evolutionary conservation of th
Page 135 and 136: A " l ... aGAP~RAGC EPOV~SR~AGQGE ;
Page 137 and 138: postulates that the first AUG codon
Page 139 and 140: Bijlsma EK, Brouwer~Mladin R, Bosch
Page 141 and 142: Tanaka N, Nishisho I, Yamamoto 1'.1
Page 143 and 144: Chapter VII Constitutional DNA-leve
Page 145 and 146:
GENES, CHROMOSOMES & CANCER 9;124-1
Page 147 and 148:
LfKANNf DfPREZ fT AL TABLE I. Cytog
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LEKANNE DEPRF2 ET AL could be that
Page 151 and 152:
Chapter VIII Frequent NF2 gene tran
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Am.'. HIIIII. Gellet. 54:1022-1029,
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Lekanne Deprez ct al. Table I Oligo
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Table 2 Nfl Gene-Transcript Mutatio
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Lebnne Deprez et lli. observed at a
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Summary and Discussion Meningioma i
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translocation (Chapter V). These hy
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were derived from patients with mor
Page 167 and 168:
Samenvatting Meningeomen zUn goedaa
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het gebied rondom het MNI gen te be
Page 171 and 172:
Curriculum vitae 30 juni 1965 gebor
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List of publications I) van 't Veer
Page 175 and 176:
Nawoord Dit boekje is 101 sland gek
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