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E BP E HP E XO D B Control: I I II II = CHROMOSOME 11 ABERRATIONS PEX X H H B B H BE !II I I I I • 0228193: - L-J 1 kb Figure 3. Physl
LEKANNE DEPRF2 ET AL could be that he is a case of mosaicism and that at least the meninges are not affected by the nmta· tions. Interestingly, he de\'cloped lung cancer at age 55 and a brain metastasis of this tumor 2 years later. Both were diagnosed as well·differcmiated adenocarcinomas, As far as we are aware, the com· bination of meningiomas and lung cancer has not been described before. ACKNOWLEDGMENTS This study was supported by a grant from the Dutch Cancer Foundation (EUR 89·06). REFERENCES ArinJmi T, Kondo I, Ham.guchi II, N1lujima.s (1',1::;6) .\Iultifoc'JI meningionlJs in J p,Hicnt with J cOllltinltiondl ring chromosome 22. J .\Icd Genct n:178-180. Illrker G, Schafer .\I, White R (I'13-t) RCllriction sitcs containing CpG sho\\' a higher frc'lucnq' ofpol)'morphilm 'In humall D;""A. Ccll 36: ]JI-U8. \-In Rielen NA, Leklnne D~prcl RH, Thijs A, lIeutink 1', OOlfll DA, GCUlts nn Ke,scl AH~I, Z\\allhoff Ee (199.1) IsoiJtion Jnd char~\.'terilation of 25 unique DNA mJrkers fOI humln chromosome 22. Genomic; IS:206-208. Dolgcr Gil, St.lmberg C~IJ, Kirsch IR, Ho1li, GF, Sdl\\JrL DF, Thonus Gil (1985) Chromosome mnslocJtiun t(l4;U) and the on(ogcnc (c'-sis) vlriant in J pedigree \Iith £JmiliJI meningiomJ. N Eng!] Med 312:564-567. BudJIf ML, McDermid HE, Sellinger B, EmJnud [IS (19')i) Js
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GENES ON CHROMOSOME 22 INVOLVED IN
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PROMOTmCOMMIssm Promotor: Prof. Dr.
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Contents List of abbreviations 9 Ch
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List of abbreviations APC bp DCC FA
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1 Cancer is a genetic disease It is
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transformation came from somatic ce
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to tumorigenesis if a mutation inac
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is that this interaction inactivate
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endogenous wt p53 by forming mixed
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Recent studies in these families ha
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In about 15% of all colon tumors an
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e explained by assuming that the nu
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3.6 The NFl gene Neurofibromatosis
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4 MENINGIOMA 4.1 Cells of origin In
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fossa and foramen magnum), convexit
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early cell cultures the presence of
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gene (Dumanski et aI., NNFF consort
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et aI., 1991b; Larsson et aI., 1990
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6 References Aaltonen LA, Peltomiik
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(1988) SV40 large tumor antigen for
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Haber DA, Buckler AJ, Glaser T, Cal
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carcinomas. Genes Chrom Cancer 2:19
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Pelletier J, Breunin~ W, Kashtan CE
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Stratton MR, Darling J, Lantos PL,
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Chapter II Isolatioll alld characte
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SHORT COMMUNICATION TABLE 1 Charact
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Appendix A lIew polymorphic probe 0
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Nudeic Acids Research, Vol. 19, No.
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Chapter III Cytogenetic, molecular
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Introduction Meningiomas are consid
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defined by evaluating 6 histologica
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number of clonal chromosomal abnorm
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#22 status No. Sex/Age (yr) Site of
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#22 slattls No. SexiAge (yr) Site o
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#22 status No. Sex/Age (yr) Site of
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Table 2. Comparison of FISH, cytoge
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No. Days in Karyotypes andlor clona
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No. Days in Karyotypes and/or clona
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to map both breakpoints (data not s
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Statistical analyses concerning age
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Tuble 4. Frequency tables between d
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from adult patients, indicating tha
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Acknowledgements This study was sup
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McDermid HE, Duncan AMV, Higgins MJ
Page 99 and 100: Chapter IV Familial anaplastic epen
Page 101 and 102: Familial anaplastic ependymoma: evi
Page 103 and 104: PATIENT A, born 1977, presented at
Page 105 and 106: Microscopic examination (patients A
Page 107 and 108: (Lekanne Deprez et aI., 1994). Tabl
Page 109 and 110: Chapter V A t(4;22) ill a meningiom
Page 111 and 112: Am. J. HI/m. Genet. 48:783-790, 199
Page 113 and 114: Putative Tumor-suppressor Gene in M
Page 119 and 120: Chapter VI Molecular clolling of a
Page 121 and 122: Molecular Cloning of a Gene Disrupt
Page 123 and 124: to playa role in the development of
Page 125 and 126: total sheared human genomic DNA bef
Page 127 and 128: Genomic cosmid contig spanning the
Page 129 and 130: probe A is conserved in hamster DNA
Page 131 and 132: Southerll, 1l0l1hern blots and evol
Page 133 and 134: The evolutionary conservation of th
Page 135 and 136: A " l ... aGAP~RAGC EPOV~SR~AGQGE ;
Page 137 and 138: postulates that the first AUG codon
Page 139 and 140: Bijlsma EK, Brouwer~Mladin R, Bosch
Page 141 and 142: Tanaka N, Nishisho I, Yamamoto 1'.1
Page 143 and 144: Chapter VII Constitutional DNA-leve
Page 145 and 146: GENES, CHROMOSOMES & CANCER 9;124-1
Page 147: LfKANNf DfPREZ fT AL TABLE I. Cytog
Page 151 and 152: Chapter VIII Frequent NF2 gene tran
Page 153 and 154: Am.'. HIIIII. Gellet. 54:1022-1029,
Page 155 and 156: Lekanne Deprez ct al. Table I Oligo
Page 157 and 158: Table 2 Nfl Gene-Transcript Mutatio
Page 159 and 160: Lebnne Deprez et lli. observed at a
Page 161 and 162: Summary and Discussion Meningioma i
Page 163 and 164: translocation (Chapter V). These hy
Page 165 and 166: were derived from patients with mor
Page 167 and 168: Samenvatting Meningeomen zUn goedaa
Page 169 and 170: het gebied rondom het MNI gen te be
Page 171 and 172: Curriculum vitae 30 juni 1965 gebor
Page 173 and 174: List of publications I) van 't Veer
Page 175 and 176: Nawoord Dit boekje is 101 sland gek
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