View PDF Version - RePub - Erasmus Universiteit Rotterdam

More documents

Recommendations

Info

170
Curriculum vitae 30 juni 1965 geboren te Oegstgeest 1984 eindexamen VWO aan het Rijnlands Lyceum te Oegstgeest 1984 - 1988 studie Gezondheidswetenschappen aan de Faculteit der Geneeskllnde Rijksllniversiteit van Leiden (cum laude) Bijvakstages: 1 Afdeling Klinische Oncologie, Academisch Ziekenhllis Leiden begeleider: Dr. P.L Schrier 2 Afdeling Klinische Oncologie, Academisch Ziekenhuis Leiden begeleider: Prof. Dr. F.J. Cleton 3 Afdeling Nierziekten, Academisch Ziekenhuis Leiden begeleider: Prof. Dr. M.R. Daha 4 Afdeling Medische Biochemie, Sylvius Laboratorium Leiden begeleider: Dr. J.A. Maassen Hoojdvakstage: Afdeling Medische Biochemie, Sylvius Laboratorium Leiden begeleider: Dr. LA. Maassen 1989 - 1994 Promotieonderzoek, afdeling Pathologie, Erasmus Universiteit Rotterdam promotor: Prof. Dr. D. Bootsma (afd. Genetica) co-promotor: Dr. B.C. Zwarthoff 1994 - Wetenschappelijk onderzoeker, afdeling Anatomie & Embryologie, Academisch Medisch Centrum, Amsterdam 171
Page 1:
GENES ON CHROMOSOME 22 INVOLVED IN
Page 4 and 5:
PROMOTmCOMMIssm Promotor: Prof. Dr.
Page 6 and 7:
Contents List of abbreviations 9 Ch
Page 9:
List of abbreviations APC bp DCC FA
Page 13 and 14:
1 Cancer is a genetic disease It is
Page 15 and 16:
transformation came from somatic ce
Page 17 and 18:
to tumorigenesis if a mutation inac
Page 19 and 20:
is that this interaction inactivate
Page 21 and 22:
endogenous wt p53 by forming mixed
Page 23 and 24:
Recent studies in these families ha
Page 25 and 26:
In about 15% of all colon tumors an
Page 27 and 28:
e explained by assuming that the nu
Page 29 and 30:
3.6 The NFl gene Neurofibromatosis
Page 31 and 32:
4 MENINGIOMA 4.1 Cells of origin In
Page 33 and 34:
fossa and foramen magnum), convexit
Page 35 and 36:
early cell cultures the presence of
Page 37 and 38:
gene (Dumanski et aI., NNFF consort
Page 39 and 40:
et aI., 1991b; Larsson et aI., 1990
Page 41 and 42:
6 References Aaltonen LA, Peltomiik
Page 43 and 44:
(1988) SV40 large tumor antigen for
Page 45 and 46:
Haber DA, Buckler AJ, Glaser T, Cal
Page 47 and 48:
carcinomas. Genes Chrom Cancer 2:19
Page 49 and 50:
Pelletier J, Breunin~ W, Kashtan CE
Page 51 and 52:
Stratton MR, Darling J, Lantos PL,
Page 53:
Chapter II Isolatioll alld characte
Page 56 and 57:
SHORT COMMUNICATION TABLE 1 Charact
Page 59:
Appendix A lIew polymorphic probe 0
Page 62 and 63:
Nudeic Acids Research, Vol. 19, No.
Page 65:
Chapter III Cytogenetic, molecular
Page 68 and 69:
Introduction Meningiomas are consid
Page 70 and 71:
defined by evaluating 6 histologica
Page 72 and 73:
number of clonal chromosomal abnorm
Page 74 and 75:
#22 status No. Sex/Age (yr) Site of
Page 76 and 77:
#22 slattls No. SexiAge (yr) Site o
Page 78 and 79:
#22 status No. Sex/Age (yr) Site of
Page 80 and 81:
Table 2. Comparison of FISH, cytoge
Page 82 and 83:
No. Days in Karyotypes andlor clona
Page 84 and 85:
No. Days in Karyotypes and/or clona
Page 86 and 87:
to map both breakpoints (data not s
Page 88 and 89:
Statistical analyses concerning age
Page 90 and 91:
Tuble 4. Frequency tables between d
Page 92 and 93:
from adult patients, indicating tha
Page 94 and 95:
Acknowledgements This study was sup
Page 96 and 97:
McDermid HE, Duncan AMV, Higgins MJ
Page 99 and 100:
Chapter IV Familial anaplastic epen
Page 101 and 102:
Familial anaplastic ependymoma: evi
Page 103 and 104:
PATIENT A, born 1977, presented at
Page 105 and 106:
Microscopic examination (patients A
Page 107 and 108:
(Lekanne Deprez et aI., 1994). Tabl
Page 109 and 110:
Chapter V A t(4;22) ill a meningiom
Page 111 and 112:
Am. J. HI/m. Genet. 48:783-790, 199
Page 113 and 114:
Putative Tumor-suppressor Gene in M
Page 115 and 116:
Page 117 and 118:
Page 119 and 120: Chapter VI Molecular clolling of a
Page 121 and 122: Molecular Cloning of a Gene Disrupt
Page 123 and 124: to playa role in the development of
Page 125 and 126: total sheared human genomic DNA bef
Page 127 and 128: Genomic cosmid contig spanning the
Page 129 and 130: probe A is conserved in hamster DNA
Page 131 and 132: Southerll, 1l0l1hern blots and evol
Page 133 and 134: The evolutionary conservation of th
Page 135 and 136: A " l ... aGAP~RAGC EPOV~SR~AGQGE ;
Page 137 and 138: postulates that the first AUG codon
Page 139 and 140: Bijlsma EK, Brouwer~Mladin R, Bosch
Page 141 and 142: Tanaka N, Nishisho I, Yamamoto 1'.1
Page 143 and 144: Chapter VII Constitutional DNA-leve
Page 145 and 146: GENES, CHROMOSOMES & CANCER 9;124-1
Page 147 and 148: LfKANNf DfPREZ fT AL TABLE I. Cytog
Page 149 and 150: LEKANNE DEPRF2 ET AL could be that
Page 151 and 152: Chapter VIII Frequent NF2 gene tran
Page 153 and 154: Am.'. HIIIII. Gellet. 54:1022-1029,
Page 155 and 156: Lekanne Deprez ct al. Table I Oligo
Page 157 and 158: Table 2 Nfl Gene-Transcript Mutatio
Page 159 and 160: Lebnne Deprez et lli. observed at a
Page 161 and 162: Summary and Discussion Meningioma i
Page 163 and 164: translocation (Chapter V). These hy
Page 165 and 166: were derived from patients with mor
Page 167 and 168: Samenvatting Meningeomen zUn goedaa
Page 169: het gebied rondom het MNI gen te be
Page 173 and 174: List of publications I) van 't Veer
Page 175 and 176: Nawoord Dit boekje is 101 sland gek
show all

View PDF Version - RePub - Erasmus Universiteit Rotterdam

Create successful ePaper yourself

Delete template?

Save as template?