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Page 1: GENES ON CHROMOSOME 22 INVOLVED IN
Page 4 and 5: PROMOTmCOMMIssm Promotor: Prof. Dr.
Page 6 and 7: Contents List of abbreviations 9 Ch
Page 9: List of abbreviations APC bp DCC FA
Page 13 and 14: 1 Cancer is a genetic disease It is
Page 15 and 16: transformation came from somatic ce
Page 17 and 18: to tumorigenesis if a mutation inac
Page 19 and 20: is that this interaction inactivate
Page 21 and 22: endogenous wt p53 by forming mixed
Page 23 and 24: Recent studies in these families ha
Page 25 and 26: In about 15% of all colon tumors an
Page 27 and 28: e explained by assuming that the nu
Page 29 and 30: 3.6 The NFl gene Neurofibromatosis
Page 31 and 32: 4 MENINGIOMA 4.1 Cells of origin In
Page 33 and 34: fossa and foramen magnum), convexit
Page 35 and 36: early cell cultures the presence of
Page 37 and 38: gene (Dumanski et aI., NNFF consort
Page 39 and 40: et aI., 1991b; Larsson et aI., 1990
Page 41 and 42: 6 References Aaltonen LA, Peltomiik
Page 43: (1988) SV40 large tumor antigen for
Page 47 and 48: carcinomas. Genes Chrom Cancer 2:19
Page 49 and 50: Pelletier J, Breunin~ W, Kashtan CE
Page 51 and 52: Stratton MR, Darling J, Lantos PL,
Page 53: Chapter II Isolatioll alld characte
Page 56 and 57: SHORT COMMUNICATION TABLE 1 Charact
Page 59: Appendix A lIew polymorphic probe 0
Page 62 and 63: Nudeic Acids Research, Vol. 19, No.
Page 65: Chapter III Cytogenetic, molecular
Page 68 and 69: Introduction Meningiomas are consid
Page 70 and 71: defined by evaluating 6 histologica
Page 72 and 73: number of clonal chromosomal abnorm
Page 74 and 75: #22 status No. Sex/Age (yr) Site of
Page 76 and 77: #22 slattls No. SexiAge (yr) Site o
Page 78 and 79: #22 status No. Sex/Age (yr) Site of
Page 80 and 81: Table 2. Comparison of FISH, cytoge
Page 82 and 83: No. Days in Karyotypes andlor clona
Page 84 and 85: No. Days in Karyotypes and/or clona
Page 86 and 87: to map both breakpoints (data not s
Page 88 and 89: Statistical analyses concerning age
Page 90 and 91: Tuble 4. Frequency tables between d
Page 92 and 93: from adult patients, indicating tha
Page 94 and 95:
Acknowledgements This study was sup
Page 96 and 97:
McDermid HE, Duncan AMV, Higgins MJ
Page 99 and 100:
Chapter IV Familial anaplastic epen
Page 101 and 102:
Familial anaplastic ependymoma: evi
Page 103 and 104:
PATIENT A, born 1977, presented at
Page 105 and 106:
Microscopic examination (patients A
Page 107 and 108:
(Lekanne Deprez et aI., 1994). Tabl
Page 109 and 110:
Chapter V A t(4;22) ill a meningiom
Page 111 and 112:
Am. J. HI/m. Genet. 48:783-790, 199
Page 113 and 114:
Putative Tumor-suppressor Gene in M
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
Chapter VI Molecular clolling of a
Page 121 and 122:
Molecular Cloning of a Gene Disrupt
Page 123 and 124:
to playa role in the development of
Page 125 and 126:
total sheared human genomic DNA bef
Page 127 and 128:
Genomic cosmid contig spanning the
Page 129 and 130:
probe A is conserved in hamster DNA
Page 131 and 132:
Southerll, 1l0l1hern blots and evol
Page 133 and 134:
The evolutionary conservation of th
Page 135 and 136:
A " l ... aGAP~RAGC EPOV~SR~AGQGE ;
Page 137 and 138:
postulates that the first AUG codon
Page 139 and 140:
Bijlsma EK, Brouwer~Mladin R, Bosch
Page 141 and 142:
Tanaka N, Nishisho I, Yamamoto 1'.1
Page 143 and 144:
Chapter VII Constitutional DNA-leve
Page 145 and 146:
GENES, CHROMOSOMES & CANCER 9;124-1
Page 147 and 148:
LfKANNf DfPREZ fT AL TABLE I. Cytog
Page 149 and 150:
LEKANNE DEPRF2 ET AL could be that
Page 151 and 152:
Chapter VIII Frequent NF2 gene tran
Page 153 and 154:
Am.'. HIIIII. Gellet. 54:1022-1029,
Page 155 and 156:
Lekanne Deprez ct al. Table I Oligo
Page 157 and 158:
Table 2 Nfl Gene-Transcript Mutatio
Page 159 and 160:
Lebnne Deprez et lli. observed at a
Page 161 and 162:
Summary and Discussion Meningioma i
Page 163 and 164:
translocation (Chapter V). These hy
Page 165 and 166:
were derived from patients with mor
Page 167 and 168:
Samenvatting Meningeomen zUn goedaa
Page 169 and 170:
het gebied rondom het MNI gen te be
Page 171 and 172:
Curriculum vitae 30 juni 1965 gebor
Page 173 and 174:
List of publications I) van 't Veer
Page 175 and 176:
Nawoord Dit boekje is 101 sland gek
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