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het onderzoek onontbeerlijk was. Beste Anne, jij stand altijd klaar am mijn manuscripten zorgvuldig na te kijken, zelfs wanneer de enige tijd diejou nag restte de vroege morgen was. Ellen van Drunen, ookjouw naam mag hier niet ontbreken. Ik heb de samenwerking metjou als zeer prettig ervaren en wil je in het bijzonder bedanken voor de cytogenetica, die jij grotendeels voor je rekening nam. I would like to thank our colleagues from Bristol Myers (Princeton, New Jersey), Bernd Seizinger, Nikolai Kley and Albert Bianchi for giving l11e the opportunity to do the mutation analyses of our series of meningiomas in their lab. Nikolai and Mary I will never forget the wonderful days at the beach and the way you taught l11e how to surf. Professor Avezaat en Jan-Willem Koper wil ik bedanken voor het respectievelijk aanleveren en in kweek brcngen van het vocr dit onderzoek zo bclangrijke meningeoma materiaal. De leden van de kleine promotiecommissie wil ik bedanken vocr het kritisch lezen van dit proefschrift. Tot slot wi! ik mijn familie en vrienden bedanken voor hun interesse en stelln. Willeke, de steun die van jou uitging is eigenlijk niet te beschrijvcn. Heel erg veel dank hiervoor. 176
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GENES ON CHROMOSOME 22 INVOLVED IN
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PROMOTmCOMMIssm Promotor: Prof. Dr.
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Contents List of abbreviations 9 Ch
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List of abbreviations APC bp DCC FA
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1 Cancer is a genetic disease It is
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transformation came from somatic ce
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to tumorigenesis if a mutation inac
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is that this interaction inactivate
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endogenous wt p53 by forming mixed
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Recent studies in these families ha
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In about 15% of all colon tumors an
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e explained by assuming that the nu
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3.6 The NFl gene Neurofibromatosis
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4 MENINGIOMA 4.1 Cells of origin In
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fossa and foramen magnum), convexit
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early cell cultures the presence of
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gene (Dumanski et aI., NNFF consort
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et aI., 1991b; Larsson et aI., 1990
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6 References Aaltonen LA, Peltomiik
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(1988) SV40 large tumor antigen for
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Haber DA, Buckler AJ, Glaser T, Cal
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carcinomas. Genes Chrom Cancer 2:19
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Pelletier J, Breunin~ W, Kashtan CE
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Stratton MR, Darling J, Lantos PL,
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Chapter II Isolatioll alld characte
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SHORT COMMUNICATION TABLE 1 Charact
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Appendix A lIew polymorphic probe 0
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Nudeic Acids Research, Vol. 19, No.
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Chapter III Cytogenetic, molecular
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Introduction Meningiomas are consid
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defined by evaluating 6 histologica
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number of clonal chromosomal abnorm
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#22 status No. Sex/Age (yr) Site of
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#22 slattls No. SexiAge (yr) Site o
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#22 status No. Sex/Age (yr) Site of
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Table 2. Comparison of FISH, cytoge
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No. Days in Karyotypes andlor clona
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No. Days in Karyotypes and/or clona
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to map both breakpoints (data not s
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Statistical analyses concerning age
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Tuble 4. Frequency tables between d
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from adult patients, indicating tha
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Acknowledgements This study was sup
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McDermid HE, Duncan AMV, Higgins MJ
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Chapter IV Familial anaplastic epen
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Familial anaplastic ependymoma: evi
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PATIENT A, born 1977, presented at
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Microscopic examination (patients A
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(Lekanne Deprez et aI., 1994). Tabl
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Chapter V A t(4;22) ill a meningiom
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Am. J. HI/m. Genet. 48:783-790, 199
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Putative Tumor-suppressor Gene in M
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Chapter VI Molecular clolling of a
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Molecular Cloning of a Gene Disrupt
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to playa role in the development of
Page 125 and 126: total sheared human genomic DNA bef
Page 127 and 128: Genomic cosmid contig spanning the
Page 129 and 130: probe A is conserved in hamster DNA
Page 131 and 132: Southerll, 1l0l1hern blots and evol
Page 133 and 134: The evolutionary conservation of th
Page 135 and 136: A " l ... aGAP~RAGC EPOV~SR~AGQGE ;
Page 137 and 138: postulates that the first AUG codon
Page 139 and 140: Bijlsma EK, Brouwer~Mladin R, Bosch
Page 141 and 142: Tanaka N, Nishisho I, Yamamoto 1'.1
Page 143 and 144: Chapter VII Constitutional DNA-leve
Page 145 and 146: GENES, CHROMOSOMES & CANCER 9;124-1
Page 147 and 148: LfKANNf DfPREZ fT AL TABLE I. Cytog
Page 149 and 150: LEKANNE DEPRF2 ET AL could be that
Page 151 and 152: Chapter VIII Frequent NF2 gene tran
Page 153 and 154: Am.'. HIIIII. Gellet. 54:1022-1029,
Page 155 and 156: Lekanne Deprez ct al. Table I Oligo
Page 157 and 158: Table 2 Nfl Gene-Transcript Mutatio
Page 159 and 160: Lebnne Deprez et lli. observed at a
Page 161 and 162: Summary and Discussion Meningioma i
Page 163 and 164: translocation (Chapter V). These hy
Page 165 and 166: were derived from patients with mor
Page 167 and 168: Samenvatting Meningeomen zUn goedaa
Page 169 and 170: het gebied rondom het MNI gen te be
Page 171 and 172: Curriculum vitae 30 juni 1965 gebor
Page 173 and 174: List of publications I) van 't Veer
Page 175: Nawoord Dit boekje is 101 sland gek
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