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SHORT COMMUNICATION Isolation and Characterization of 25 Unique DNA Markers for Human Chromosome 22 NICK A. VAN BIEZEN, '" RONALD H, LEKANNE DEPREZ," ABEL THIJS, '" PETER HEUTINK, t BEN A. OaSTRA, t AD H. M, GEURTS VAN KessEl,:f: AND EllEN C. ZWARTHOFF*,l 'Department of Pathology, Erasmus University, Rotterdam; tDepartment of Clinical Genetics, Rotterdam; and tDepartment of Human Genetics, University of Nij'megen, Nijmegen, The Netherlands Twenty-five single-copy anonymous DNA markers for human chromosome 22 were Isolated. These markers wore assigned to four different regions on the chromosome. Sb; markers recognize restriction fragment length polymorphlsms. The relative positions of five of these polymorphic markers on the Cramework map of chromosome 22 were determined by linkage analysis. The sizes of the Noll fragments recognized by 22 markers were determined by pulsed-field gel analysIs. The total length of the Noll fragmentsldentlfled is at least 12 Mh, which represents about 20% of the en Ure chromosome. t> 1993 A
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GENES ON CHROMOSOME 22 INVOLVED IN
Page 4 and 5: PROMOTmCOMMIssm Promotor: Prof. Dr.
Page 6 and 7: Contents List of abbreviations 9 Ch
Page 9: List of abbreviations APC bp DCC FA
Page 13 and 14: 1 Cancer is a genetic disease It is
Page 15 and 16: transformation came from somatic ce
Page 17 and 18: to tumorigenesis if a mutation inac
Page 19 and 20: is that this interaction inactivate
Page 21 and 22: endogenous wt p53 by forming mixed
Page 23 and 24: Recent studies in these families ha
Page 25 and 26: In about 15% of all colon tumors an
Page 27 and 28: e explained by assuming that the nu
Page 29 and 30: 3.6 The NFl gene Neurofibromatosis
Page 31 and 32: 4 MENINGIOMA 4.1 Cells of origin In
Page 33 and 34: fossa and foramen magnum), convexit
Page 35 and 36: early cell cultures the presence of
Page 37 and 38: gene (Dumanski et aI., NNFF consort
Page 39 and 40: et aI., 1991b; Larsson et aI., 1990
Page 41 and 42: 6 References Aaltonen LA, Peltomiik
Page 43 and 44: (1988) SV40 large tumor antigen for
Page 45 and 46: Haber DA, Buckler AJ, Glaser T, Cal
Page 47 and 48: carcinomas. Genes Chrom Cancer 2:19
Page 49 and 50: Pelletier J, Breunin~ W, Kashtan CE
Page 51 and 52: Stratton MR, Darling J, Lantos PL,
Page 53: Chapter II Isolatioll alld characte
Page 57: SHORT COMMUNICATION ACKNOWLEDG~IENT
Page 61 and 62: Nuefeic Adds Research, Vol. 19, No.
Page 63: Nucleic Acids Research, Vol, 19, No
Page 67 and 68: Cytogenetic, Molecular Genetic and
Page 69 and 70: abnormalities, histopathological an
Page 71 and 72: D22S193, D22Sn, D22S56 and NF2 were
Page 73 and 74: (71 %) of the 93 meningiomas comple
Page 75 and 76: #22 status No. Sex/Age (y,) Site of
Page 77 and 78: #22 status No. SexlAge (yr) Site of
Page 79 and 80: #22 status No. Sex/Age (yr) Site of
Page 81 and 82: Table 3. Summary of chromosomal fin
Page 83 and 84: No. Days in Karyotypes and/or clona
Page 85 and 86: No. Days in Karyotypes and/or clona
Page 87 and 88: 112 12.1 122 123 1).1 132 133 .. '
Page 89 and 90: abnormalities were found, whereas i
Page 91 and 92: Discussion This series of meningiom
Page 93 and 94: finding that the majority of grade
Page 95 and 96: Dumanski JP, Roule~lU GA, Nordenskj
Page 97: Zucman J, Delattre 0, Desmaze C, Pl
Page 100 and 101: 100
Page 102 and 103: observed in 12 out of 30 analysed e
Page 104 and 105:
A B c Figure 2. Cerebral scans. A.
Page 106 and 107:
Genetic analysis Fresh tumor tissue
Page 108 and 109:
chromosome 22 in a major percentage
Page 110 and 111:
110
Page 112 and 113:
Lekanne Deprez et al. matosis 2 (NF
Page 114 and 115:
Lekanne Deprez et a!. Figure I Basi
Page 116 and 117:
Lekanne Deprez et al. A S ""'~"' n
Page 118 and 119:
Lekanne Deprez et aL beling DNA res
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120
Page 122 and 123:
Introduction Meningiomas are primar
Page 124 and 125:
Hybrid cell lines, The somatic cell
Page 126 and 127:
6A (data not shown), These data sug
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Isolation and characterization of t
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probably caused by the less efficie
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A 1 2 3 4 5 6 7 8 kb 9.5 7.5 4.4 2.
Page 134 and 135:
cDNA sequence analysis Sequence ana
Page 136 and 137:
Discussion Characterization of the
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involve loss of both the MNl and th
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D, van der Kwast TH, Zwarthoff BC (
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142
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144
Page 146 and 147:
CHROMOSOME 11 ABERRATIONS ebellopon
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E BP E HP E XO D B Control: I I II
Page 150 and 151:
150
Page 152 and 153:
152
Page 154 and 155:
NF2 Mut.nions and Meningiomas vatin
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NF2 Mutations and Meningiomas A D B
Page 158 and 159:
NF2 Mutations and Meningiomas Table
Page 160 and 161:
NF2 Mutations and Meningiomas Natio
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chromosomal abnormalities and tumor
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expression of the MNI gene in one o
Page 166 and 167:
166
Page 168 and 169:
wijzen, die rnogelijk voor rneninge
Page 170 and 171:
170
Page 172 and 173:
172
Page 174 and 175:
1) Lekanne Deprez RH, Groen NA, Lou
Page 176:
het onderzoek onontbeerlijk was. Be
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