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Contents
List of abbreviations 9
Chapter I Gene1'31 introduction 11
I Cancer is a genetic disease 13
2 Oncogenes and tumor suppressor genes 14
2.1 Oncogenes 14
2.2 Tumor suppressor genes 14
3 Molecular cloning and function of tumor suppressor genes 18
3.1 The Retinoblastoma (RbI) gene 18
3.2 Thep53 gene 19
3.3 The isolation of APC, MCC, DCC, hMSH2,
and hMLHl and their putative role in
colorectal tumorigenesis 22
3.4 The isolation of the wn and VHL genes 25
3.5 The RET proto-oncogene 27
3.6 The NFl gene 29
3.7 The NF2 gene 29
4 MENINGIOMA
4.1 Cells of origin 31
4.2 Frequency, incidence and occurrence 31
4.3 Anatomic localization 32
4.4 Histopathology 33
4.5 Etiology 34
4.6 Cytogenetic and molecular genetic studies
of meningiomas 35
4.7 Other tumors with loss or rearrangements
of chromosome 22 38
4.8 Chromosome 22 39
5 Scope of the thesis 40
6 References 41
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