Lekanne Deprez et aL beling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132:6-13 Finlay CA, Hinds PW, Levine AJ (1989) The p53 protooncogene can act as a suppressor of transformation. Cell 57:1083-1093 Gessler l\.1, Poustka A, Cavence W, Neve RL, Orkin SH, Bruns GAP (1990) Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature 343:774-778 Genrts van Kessel AHM, ten Brinke H, Boere WAM, den Boer \'\IC, de Groot PG, Hagcmeijer A, t-,·Ieera Khann P, et al (1981) Characterization of the Philadelphia chromosume hy gene mapping. Cytogenet Cell Genet 30;83-91 Heisterkamp N, Groffen J, Stephenson JR (1983) The human v-abl celluLlr homolog. J Mol Appl Genet 2:57-68 Heisterkamp N, SWill K, GroffenJ, de Klein A, Grosveld G (1985) Structural organization of the her gene :lnd its role in the Ph' translocation. Nature 315:758-761 Julier C, Lathrop GM, Reghis A, Szajnert !>.l-F, Lalouel ]-M, Kaplan J-C (1988) A linkage and physical map of chromosome 22, and some applications to gene mapping. Am J Hwn Genet 42:297-308 Katsuyama J, Papenhausen PR, Herz F, Gazivoda P, Hirano A, Koss LG (1986) Chromosome abnormalities in meningiomas. Cancer Genet Cytogenet 22:63-68 Koper JW, FoekensJA, Braakman R, Lamberts SWJ (1990) Effects of progesterone on the response to epidermal growth factor and other growth factors in cultured human meningioma cells. Cancer Res 50:2604-2607 McKeon C, ThieleCJ, Ross RA, Kwan }"[, Triche Tj, Miser jS, Israel MA {I 988) Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepithelioma. Cancer Rcs 48:4307-4311 Maltby EL, Ironside JW, Battersby RDE (1988) Cytogenetic studies in 50 meningiomas. Cancer Genet Cytogenet 31: 199-210 Meese E, Blin N, Zang KD (1987) Loss of heterozygosity and the origin of meningioma. Hum Genet 77:349-351 Nakamura Y, Culver M, O'Connell P, Leppert M, Lathrop GM, LalouelJM, White R (1988) Isolation and mapping of a polymorphic DNA sequence (pYNZ32) on chromosome 4p [D4S125}. Nucleic Acids Res 16:4186 Poulsgard L, R
Chapter VI Molecular clolling of a gene disrupted by a balanced trallslocation in a meningioma to be submilted 119
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GENES ON CHROMOSOME 22 INVOLVED IN
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PROMOTmCOMMIssm Promotor: Prof. Dr.
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Contents List of abbreviations 9 Ch
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List of abbreviations APC bp DCC FA
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1 Cancer is a genetic disease It is
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transformation came from somatic ce
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to tumorigenesis if a mutation inac
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is that this interaction inactivate
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endogenous wt p53 by forming mixed
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Recent studies in these families ha
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In about 15% of all colon tumors an
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e explained by assuming that the nu
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3.6 The NFl gene Neurofibromatosis
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4 MENINGIOMA 4.1 Cells of origin In
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fossa and foramen magnum), convexit
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early cell cultures the presence of
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gene (Dumanski et aI., NNFF consort
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et aI., 1991b; Larsson et aI., 1990
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6 References Aaltonen LA, Peltomiik
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(1988) SV40 large tumor antigen for
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Haber DA, Buckler AJ, Glaser T, Cal
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carcinomas. Genes Chrom Cancer 2:19
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Pelletier J, Breunin~ W, Kashtan CE
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Stratton MR, Darling J, Lantos PL,
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Chapter II Isolatioll alld characte
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SHORT COMMUNICATION TABLE 1 Charact
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Appendix A lIew polymorphic probe 0
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Nudeic Acids Research, Vol. 19, No.
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Chapter III Cytogenetic, molecular
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- Page 99 and 100: Chapter IV Familial anaplastic epen
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- Page 103 and 104: PATIENT A, born 1977, presented at
- Page 105 and 106: Microscopic examination (patients A
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- Page 137 and 138: postulates that the first AUG codon
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- Page 143 and 144: Chapter VII Constitutional DNA-leve
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- Page 147 and 148: LfKANNf DfPREZ fT AL TABLE I. Cytog
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- Page 155 and 156: Lekanne Deprez ct al. Table I Oligo
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- Page 163 and 164: translocation (Chapter V). These hy
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het gebied rondom het MNI gen te be
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Curriculum vitae 30 juni 1965 gebor
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List of publications I) van 't Veer
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Nawoord Dit boekje is 101 sland gek