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CHROMOSOME 11 ABERRATIONS ebellopontine angle and intraspinally. In 1987, several pamsagittal meningiomas were removed surgically. The tumors were histologically diagnosed as fibrous meningiomas (designated ~[N55A). In December 1989, a reCLlrrence of a parasagittal meningioma on the left side was removed and histologically diagnosed as a fibrous meningioma (:..tN55B). Multiple small nodules of hyperplasia were observed in this region. In October 19l)O, two meningiomas from the right (:"IN55C) and the left (i\IN550) cerebellopolltine angle were excised at an inten'al of 2 weeks; both were of the fibrous type. The patient's parents have no history of meningiomas. However, her t~lther (born in 1929) developed a well-differentiated adenocarcinoma of the lung in 19H4 and 2 years latera brain metastasis of this tumor. A CT scan performed in 1990 did not reveal any intracmnial tumors. When this paper W,IS written, he was alive ilntl without complaints. Tissue Culture and Cytogenetic Analysis The meningioma specimens (MN55B,C,D) were ohtained within 3{) min after surgery. The preparation for tissue culture and tissue culture l'Onditions were as described (Koper et aI., 1990). Chromosome analysis WilS carried Ollt on cultured cells after one to three passages using R-(acridine omnge) and Q-(quinacrine) banding. The karyotypes were described aCl'onling to ISeN (1991). DNA Extraction, Southern Blotting, and Hybridization High molecular weight DNA was isolated from I:ultured and fresh tumor ti.~sue and peripheral blood leucocytes from the patient, her parents, and unrelated individuals according tu standard procedures. The percentage of tumor cells in the fresh tumor sample was est,lhlished by microscopic examination of a frozen tissue section. DNA analyses were performed as reported by Lekanne Deprez e( a!. (199b). The following DNA markers for loci on chromosome 22 were used: D2ZSIHI, D2ZS183 (Lekanne Deprez et aI., 1
LfKANNf DfPREZ fT AL TABLE I. CytogenetiC Findings In Meningioma Tumors from Patient 55 Passage No. of Tumor '0 cells # culture karyotyped MN5SA Not done MNSSB pO IS (primary outgrowth) MNSSC pi 25 MNS5D p) Karyotype 4S,XX, - 22[ I JI44,X, - X, - 22{8]140-H, idem, with random losses [5] 4S,XX,-22[24]/89, hypotetrap!old, -22, -22, with additional losses and rearrangements II] 4S,XX, - 22[ 31/46,XX[2] kb opment of meningioma, we used different chromosome 22 specific probes, One of thc probcs, D22St9J, which ha
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GENES ON CHROMOSOME 22 INVOLVED IN
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PROMOTmCOMMIssm Promotor: Prof. Dr.
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Contents List of abbreviations 9 Ch
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List of abbreviations APC bp DCC FA
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1 Cancer is a genetic disease It is
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transformation came from somatic ce
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to tumorigenesis if a mutation inac
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is that this interaction inactivate
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endogenous wt p53 by forming mixed
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Recent studies in these families ha
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In about 15% of all colon tumors an
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e explained by assuming that the nu
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3.6 The NFl gene Neurofibromatosis
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4 MENINGIOMA 4.1 Cells of origin In
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fossa and foramen magnum), convexit
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early cell cultures the presence of
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gene (Dumanski et aI., NNFF consort
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et aI., 1991b; Larsson et aI., 1990
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6 References Aaltonen LA, Peltomiik
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(1988) SV40 large tumor antigen for
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Haber DA, Buckler AJ, Glaser T, Cal
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carcinomas. Genes Chrom Cancer 2:19
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Pelletier J, Breunin~ W, Kashtan CE
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Stratton MR, Darling J, Lantos PL,
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Chapter II Isolatioll alld characte
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SHORT COMMUNICATION TABLE 1 Charact
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Appendix A lIew polymorphic probe 0
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Nudeic Acids Research, Vol. 19, No.
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Chapter III Cytogenetic, molecular
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Introduction Meningiomas are consid
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defined by evaluating 6 histologica
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number of clonal chromosomal abnorm
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#22 status No. Sex/Age (yr) Site of
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#22 slattls No. SexiAge (yr) Site o
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#22 status No. Sex/Age (yr) Site of
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Table 2. Comparison of FISH, cytoge
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No. Days in Karyotypes andlor clona
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No. Days in Karyotypes and/or clona
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to map both breakpoints (data not s
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Statistical analyses concerning age
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Tuble 4. Frequency tables between d
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from adult patients, indicating tha
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Acknowledgements This study was sup
Page 96 and 97: McDermid HE, Duncan AMV, Higgins MJ
Page 99 and 100: Chapter IV Familial anaplastic epen
Page 101 and 102: Familial anaplastic ependymoma: evi
Page 103 and 104: PATIENT A, born 1977, presented at
Page 105 and 106: Microscopic examination (patients A
Page 107 and 108: (Lekanne Deprez et aI., 1994). Tabl
Page 109 and 110: Chapter V A t(4;22) ill a meningiom
Page 111 and 112: Am. J. HI/m. Genet. 48:783-790, 199
Page 113 and 114: Putative Tumor-suppressor Gene in M
Page 119 and 120: Chapter VI Molecular clolling of a
Page 121 and 122: Molecular Cloning of a Gene Disrupt
Page 123 and 124: to playa role in the development of
Page 125 and 126: total sheared human genomic DNA bef
Page 127 and 128: Genomic cosmid contig spanning the
Page 129 and 130: probe A is conserved in hamster DNA
Page 131 and 132: Southerll, 1l0l1hern blots and evol
Page 133 and 134: The evolutionary conservation of th
Page 135 and 136: A " l ... aGAP~RAGC EPOV~SR~AGQGE ;
Page 137 and 138: postulates that the first AUG codon
Page 139 and 140: Bijlsma EK, Brouwer~Mladin R, Bosch
Page 141 and 142: Tanaka N, Nishisho I, Yamamoto 1'.1
Page 143 and 144: Chapter VII Constitutional DNA-leve
Page 145: GENES, CHROMOSOMES & CANCER 9;124-1
Page 149 and 150: LEKANNE DEPRF2 ET AL could be that
Page 151 and 152: Chapter VIII Frequent NF2 gene tran
Page 153 and 154: Am.'. HIIIII. Gellet. 54:1022-1029,
Page 155 and 156: Lekanne Deprez ct al. Table I Oligo
Page 157 and 158: Table 2 Nfl Gene-Transcript Mutatio
Page 159 and 160: Lebnne Deprez et lli. observed at a
Page 161 and 162: Summary and Discussion Meningioma i
Page 163 and 164: translocation (Chapter V). These hy
Page 165 and 166: were derived from patients with mor
Page 167 and 168: Samenvatting Meningeomen zUn goedaa
Page 169 and 170: het gebied rondom het MNI gen te be
Page 171 and 172: Curriculum vitae 30 juni 1965 gebor
Page 173 and 174: List of publications I) van 't Veer
Page 175 and 176: Nawoord Dit boekje is 101 sland gek
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