View PDF Version - RePub - Erasmus Universiteit Rotterdam

Cytogenetic, Molecular Genetic and Pathological
Analyses in 126 Meningiomas
Ronald H. Lekanne Deprez*, Peter H. Riegman*, Ellen van Drunen#, Ursula L. Warringa*,
Nicole A, Groen', Stanislav Z, Stefanko', Jan W, Koper@, Cees LJ, Avezaat$, Paul G, H,
Mulder&, Ellen C, Zwarthoff', and Anne Hagemeijer#1
Departments of *Pathology, HCell Biology and Genetics, @Internal Medicine, $Neurosurgery, and &Epidemiology
and Biostatistics, Erasmus University, Rotterdam
Abstract
In a series of 126 meningiomas, tumor and patient characteristics wer'c investigated and
statistically analyzed. A combined cytogenetic and molecular genetic approach was used
to study chromosomal abnol'malities and loss of markel'S OIl chromosome 22q. This
approach was successfully applied to 93 meningiomas, In 66 cases complete or partial
loss of chromosome 22 was observed and in at least 12 of them this chromosome was
involved in structural abel'l'ations. In addition to chromosome 22 changes, chromosomes
1, 6, 11, 13, 14, 18, 19, X, and Y were also frequently involved in strue!u ... 1 and
numerical aberrations. Statistical analysis revealed a significant association between the
number of chromosomal abnormalities and tumor grade. Complex karyotypes
predominated in the group of grade II/III meningiomas. FUI'thel1110re, othel' variables
showed statistically (Ol' marginally statisticall,Y) significant differences. Meningiomas
from the convexity wel'e mOl'e often gl'ade IlIIII, displayed predominantly (pa.'lia]) loss
of chromosome 22 and had complex km'yotypes more often. These features were
fl'equently found in meningiomas from males. Base meningiomas on the other hand
occurred more often in females, they were usually grade I, showed loss of (palis 00
chromosome 22 less often and displayed fewer additional clll'omososmal abn0l111aJities.
67