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#22 status
No.
Sex/Age
(yr)
Site of
Tumor
Origin l
Histological
Subtype
(grade)l
Karyotype 2
FISH(% loss)]
180
F176
B
T(O
20 9 %(dir) ns
181
F/42
c
T (I)
183
M/56
c
T (ID
49%(dir)
1 The abbreviations are given in the methodology section,
2 For more details see table 3, -22 = clonal loss of one #22 in all or part of the metaphases; 2n = two normal #22;
der(22) = partial deletion of #22 due to structural rearrangement; C = complex karyotype (> 2 chromosomal
abnormalities); ? = cytogenetic analysis failed to draw a reliable conclusion,
] % of nuclei showing one spot for the #22 specific markers (see methods), Dir = fresh tumor; PO = primairy
outgrowth of the tumor; PI = first pa~sage in culture; P2 = second passage etc,; ns = no significant loss of#22
markers,
4 LOR = Loss of heterozygosity for #22 specific polymorphic markers (see methods), -22 = loss of at least two
#22 specific polymorphic markers; 2n = no loss of #22 observed; der(22) = partial deletion of #22 (see figure I);
oi = not informative; .. = polymorphic tor only one marker, which shows loss; ne = not conclusive, for technical
rea~ons,
5 No,S5 A,B,C and D are meningiomas obtained from a patient with multiple meningioma~ (Lekanne Deprez et aI.,
1994).
6 No.60 and No,121 are 2 meningiomas found in 2 sisters from an NF2 familY (Delle man et aI., 1978).
J No,78 and No.94. Tumor 94 is a recurrence 01 tumor 78.
8 No.164 and No, 172, Two meningiomas located at different sites from one patient.