XXII. BIOCHEMICKÝ ZJAZD - Jesseniova lekárska fakulta

Lectures
oxidaTIve rISK IN aTHErOSCLErOSIS
Jana Muchová 1 , Zuzana Nagyová 2 , Iveta Ondrejovičová 1 and Zdeňka Ďuračková 1
1
Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry,
Medical School, Comenius University, Bratislava, Slovakia;
2
Juvenalia, Paediatric Center, Dunajská Streda, Slovakia;
Atherosclerosis is the most common pathological process that leads to cardiovascular
diseases and is known to be associated with inflammation, oxidative stress and endothelial
dysfunction. In the vasculature reactive oxidant species may oxidatively modify
lipids and proteins with deleterious consequences for vascular function. The ROS are
common by-products of many oxidative biochemical and physiological processes. They
can be released by increased activation of xanthine oxidase, NAD(P)H oxidase, lipoxygenases,
mitochondria, or the uncoupling of nitric oxide synthase in vascular cells, as
well as decreased cellular antioxidant capacity. ROS mediate various signaling pathways
that underlie vascular inflammation in atherogenesis. The dysfunctional vasculature is
characterized by lipid peroxidation and aberrant lipid deposition, inflammation, immune
cells cell activation, platelet activation, thrombus formation, and disturbed hemodynamic
flow. Each of these pathological states is associated with increasing of free radical
species-derived oxidation products and, thereby, implicates increased oxidant stress in
the pathogenesis of vascular diseases.
84 XXII. Biochemistry Congress, Martin