XXII. BIOCHEMICKÝ ZJAZD - Jesseniova lekárska fakulta

Lectures
XENOBIOTIC-METABOLIZING ENZYMES POLYMORPHISMS
AND CANCER RISK
Monika Kmeťová Sivoňová 1 , Dušan Dobrota 1 , Tatiana Matáková 1 , Zuzana Tatarková 1 ,
Mária Kovalská 1 , Martina Pavlíková 1 , Róbert Dušenka 2 and Ján Kliment 2
1
Department of Medical Biochemistry, Comenius University, Jessenius Faculty
of Medicine, Martin, 2 Department of Urology, Comenius University, Jessenius Faculty
of Medicine and University Hospital, Martin
Research in the past few years has shown that genetic, socioeconomic and environmental
factors, particularly diet and lifestyle can affect the process of carcinogenesis.
It is assumed that increased exposure to procarcinogens and carcinogens contained in
tobacco smoke, debris, fermented food, polluted water, air etc., is implicated in multistage
carcinogenesis. Xenobiotic-metabolizing enzymes play a key role in the metabolism of
drugs and environmental chemicals and in the metabolic activation and detoxification
of procarcinogens. Phenotyping analyses have revealed an association between these
enzymes activities and the risk of developing several forms of cancer. The gene polymorphism
of xenobiotic-metabolizing enzymes can cause interindividual differences in
the activation/inactivation of anticancer agents/carcinogens and understanding of the
contribution of these enzymes gene polymorphisms and their interactions with other
relevant factors may improve screening diagnostic assays for cancer.
Acknowledgements: This work was supported by grants MH SR 2007/45-UK-10, MH SR
2007/57-UK-17, MVTS Bil/ČR/SR/UK/06, AV 4/0013/05 and project “Center of Translational
Medicine” co-financed from EC sources and European Regional Development Fund.
94 XXII. Biochemistry Congress, Martin