trans

FURTHER READING 87
inhibition, it may instead be possible to affect
them by attacking upstream processes. The differentiation
of an African trypanosome is initiated
by external environmental signals. These
signals have to be carried to the degradation
apparatus, in order to increase the degradation
of some mRNAs and stabilize and increase
translation of others. The regulation of AREmediated
degradation in mammalian cells has
been shown to involve the kinase cascades,
and kinases are being extensively investigated
as possible drug targets, for example for anticancer
chemotherapy. If post-transcriptional
regulation is to be disrupted in kinetoplastids,
it is probably the signalling kinases that will be
the most appropriate targets for attack.
FURTHER READING
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MOLECULAR BIOLOGY