trans

476 INDEX
Maduramicin, 412
Major variant erythrocyte surface proteins,
107
Malaria, see Plasmodium
Malate:ubiquinone oxidoreductase, 164–5
Malate dehydrogenase, 130, 164
Maltase, 329, 330
Manan-like carbohydrate, 237
Mannitol 1-phosphatase, 167
Mannitol 1-phosphate dehydrogenase,
166–7
inhibitors, 167–8
Mannitol cycle, 166, 168
Mannitol dehydrogenase, 167
Mansonella streptocerca, 458
Map-based genome sequencing, 10–11
MDR1, 417
mdr1a, 333
Mebendazole, 460
mec-8, 317, 318
Mefloquine, 440, 441, 442, 443–5
resistance, 406–7, 443
structure, 401, 440
Megasome, 180
Megazol, 432
Meglumine antimonate, 413, 451
Melarsen oxide, 147
Melarsoprol, 412, 419, 430, 448, 450
mode of action, 419
resistance, 419, 448
Meloidogyne,20
Membrane-bound acid phosphatase, 237
Mesocestoides corti, 392
Metagonimus yokogawi, 458
Metalloproteinases, 174, 176–7, 178, 179, 180
Methionine:
catabolism, 185, 186
polyamines synthesis, 189–91
recycling, 185, 186
Methionine adenosyltransferase, 191
Methionine -lyase, 185
Methotrexate resistance, 418
Methylene blue dye, 439, 440
5 Methylthioadenosine (MTA) nucleosidase,
185
5 Methylthioadenosine (MTA) phosphorylase,
185
5-Methylthioribose kinase, 185
Methyridine, 368
Metorchis conjunctus, 458
Metrifonate (trichlorfon), 367, 389
Metronidazole, 432, 438, 453–4
mode of action, 135, 284, 453
resistance:
Entamoeba histolytica, 426
Giardia duodenaslis, 425
Trichomonas vaginalis, 424–5
structure, 414
Microaerophilic organisms, 126
Microsporidia, 125, 283
Microtriches, 298
biochemistry/molecular biology, 299
Miltefosine, 414, 452, 453
resistance, 417
Mitochondria, 277
Ca 2 transport, 242, 243–5
endosymbiosis:
reduction processes, 279–80
theory, 277–9
kinetoplastids, 281–2
metabolism, 280–2
drug targets, 281
Plasmodium, 281
targeting of nucleus encoded gene products,
280
Mitochondrial energy metabolism, 278
helminths, 339–40, 344–53, 354
Plasmodium falciparum, 161–5
citric acid (TCA) cycle, 164–5
electron transport, 161–3
oxidative phosphorylation, 163–4
Mitochondrial genome, 278
evolutionary reduction, 279
intracellular gene transfer, 279–80
nematodes, 25
Plasmodium, 161, 281
RNA editing processes, 38
see also Kinetoplast
Mitogen-activated protein (MAP) kinase:
gene expression regulation, 268
intracellular signaling, 266–70
protozoan parasites, 268–70
apicomplexans, 268–9
Giardia, 168, 270
kinetoplastids, 269–70
scaffold proteins, 267
three-kinase activation, 266–7
Mitosome (cryptome), 126, 282
Monesia expansa, 392
Monesin, 412
Moniezia benedeni, 222
Morantel, 368