trans

464 INDEX
Aldolase, 143
Plasmodium falciparum, 159
trypanosomes, 145–6
Allantoic acid, 208
Allantoin, 208
Allopurinol, 418, 452
1-giardin, 251
-glucosidase, 128
-proteobacteria, 278
Alternative polyadenylation sites, 69
Alternative splicing, 69
fMRFamide-related peptides (FaRPs), 382
Amino acid metabolism, 171–94
amino nitrogen disposal, 182–3
biosynthesis, 188, 189
catabolism, 183–8
folate, 192, 193
glutathione synthesis, 192–3
lipid synthesis, 191–2
nitric oxide synthesis, 191
osmotic stress responses, 193–4
polyamines synthesis, 189–91
uptake, 172–3, 301, 306, 307, 318, 330
Amino acid transport, 172–3
cestodes, 301
nematodes, 318, 330
trematodes, 306, 307
Aminopeptidases, 173
Aminotransferases, 171, 182–3
Amitochondriate organisms, 125, 126,
282–5
energy metabolism, 126–7, 136–7, 284
carbohydrate fermentation end-products,
127
carbohydrate sources, 127
enzyme level regulation, 134–5
iron–sulfur center-mediated electron
transfer, 133
mitochondiate cell enzymatic differences,
133–4
nitroimidazole drug actions, 135–6, 284
oxygen effects, 134
subcellular organization, 127–8
Type I organisms, 127, 128, 130, 133
Type II organisms, 127, 128, 130, 133
evolutionary aspects, 136–7, 282–4
purine metabolism, 215–17
pyrimidine metabolism, 198, 206, 221–2
Ammonia excretion, 171, 183
Ammonia metabolism, 208
Ammonotelic metabolism, 171
Amodiaquine:
mode of action, 405
resistance, 405–6
structure, 401
Amoebopain, 175
AMP deaminase, 208, 214, 215
Amphotericin B, 413, 414, 450, 451
resistance, 417
Amylase, 329
Amylopectin, 155
apicomplexan storage granules, 166
Anaerobic organisms, 126
drug resistance, 423–6
Ancylostoma braziliense, 456
Ancylostoma caninum, 178, 179
Ancylostoma celeyanicum, 183
Anhydrobiotic survival, nematodes, 321, 323
Annexins, 251
Anopheles, 4, 5
Anopheles gambiae,26
Anoplocephalia perfoliata, 388
Anti-cholinesterase antihelmintics, 367, 389
resistance, 367–8
Antigenic variation, 73, 89–108
malaria, 22, 106–8
major variant antigens, 107
medical applications, 108
transcription regulation, 57, 58
trypanosomes, 29–30, 91–106
host immune response, 103–4
variant surface glycoproteins (VSGs), 30, 91, 226
expression regulation/switching, 99–102
genetic aspects, 97–103
role of telomeres, 100
switching rates, 102
Antihelmintics, 426, 427
anti-cholinesterases, 367–8
cholinergic receptor, 368–9, 388–9
filarial disease, 457–8
intestinal worms, 455–7
mode of action, 359, 360, 362
nematode cuticle absorption, 326, 327
resistance, 367–8, 426–8
Antimalarial drugs, 439–46
current status, 441–2
historical aspects, 439–42
prophylaxis, 441–2
resistance, 399–412, 430, 438, 439, 440, 443, 444,
445, 446
structure, 401
Aphelenchus avenue, 322