trans

INDEX 465
Apicomplexans, 437
drug resistance, 399–413
energy metabolism, 154–69
carbohydrate storage, 166–8
developmental variation, 165–6
medical significance, 168–9
gene transcription, 58–9
genomes, 21–2
mitogen-activated protein (MAP) kinases,
268–9
plastids/apicoplasts, 287, 289, 290
therapeutic targeting, 292–3
protein phosphatases, 273–4
purine metabolism, 201–3, 209–12
pyrimidine metabolism, 219–20
RNA processing regulation, 85–6
Apicoplast, 288, 289
function, 291–2
origin, 289–91
protein targeting, 292
therapeutic targeting, 291, 292–3
APT, 197
Aqueporins, 322
nematodes, 326
Arabidopsis thaliana,13
Archezoa hypothesis, 283, 284
Arecoline, 388
Arginine:
catabolism, 183–4
nitric oxide synthesis, 191
polyamines synthesis, 189–91
transport, 172–3
Arginine decarboxylase, 190
Aromatic amino acid catabolism, 187–8
Aromatic L--hydroxy acid dehydrogenase,
187, 188
Arsenicals, 419
resistance, 419–20
Artemisia annua, 411, 439
Artemisinin, 411, 439, 445
mode of action, 411
resistance, 411
Arthropod vectors, 74
African trypanosomes, 90
expressed sequence tag (EST)
datasets, 9
genomes, 26
Leishmania, 112, 113
malaria control, 441
Artioposhtia triangulata, 392
Ascaridia galli, 353
Ascaris:
genome, 24
size, 4, 20, 23
mitochondrial genomics, 25
proteinase inhibitors, 179
pyrimidine metabolism, 222
RNA trans-splicing, 33, 35
Ascaris lumbricoides, 360
chemotherapy, 456, 457
clinical aspects, 455
cuticle, 315
purine metabolism, 217
spliced leader (SL) RNA/U1 small nuclear RNA
(snRNA) gene transcription, 60
Ascaris suum, 297, 312, 360
alimentary tract, 328, 329
defecation, 334
digestive processes, 329, 330
anatomy, 360, 362, 363
nervous system, 364–5
pharyngeal muscle, 364
cuticle, 313, 315, 316
drug absorption, 326, 327
energy metabolism, 339
developmental changes, 354, 355
glycogen, 340
glycolysis, 343, 344
mitochondria, 345, 346, 347–50, 351, 352, 353
excretion, 325, 326, 333
genome, 23
hydrostatic skeleton, 317, 321
inorganic ion transport, 319, 320–1, 332
life cycle, 311–12
muscle cells, 362–4
arm, 363–4
membrane potential, 365–6
muscle bag, 363
spindle, 362–3
neurophysiology, 365–6
acetylcholine receptors, 368, 371
cholinesterase, 366–7
FaRPs, 380, 381, 383
GABA, 372
glutamate, 373, 375
5-hydroxytryptamine, 378
nitric oxide, 384
neurotransmitters, 359, 366–84
nitric acid synthase, 191
nutrient absorption, 318, 330
osmoregulation, 321, 322, 331
tubular system, 336