trans

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nature of the pathways regulated by these
proteins. Critical processes such as parasite
differentiation, growth, division or infectivity
appear to be affected. The discovery of more
specific inhibitors is predicted in the future
as studies on signal pathways become more
refined. Completion of genome sequences
coupled with developments in microarray
technologies, knockout methodologies and
proteomics will speed this research. Key areas
of future research include the identification of
extracellular triggers that activate the intracellular
signal pathways, characterization of signal
anchor proteins that localize cell responses
despite global production of signal molecules,
and assignment of the many signal components
into functional interacting pathways.
ACKNOWLEDGMENTS
The authors wish to thank Siglinde Quirk,
University of Central Florida, for assistance
with the graphics, and also David Baker and
Martin Taylor, London School of Hygiene and
Tropical Medicine, for their critical review of
portions of the chapter. Research by the
authors was supported by NIH grants AI24627
(L. R.) and AI48036 (D. C.), and by the Wellcome
Trust and British Heart Foundation (J. M. K.).
FURTHER READING
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