trans

INDEX 467
cell functions, 255–6
homeostatic pathways, 243–51
acidocalcisomes, 248–50
endoplasmic reticulum, 245–8
mitochondrial transport, 243–5
plasma membrane transport, 250–1
Calcium-binding proteins, 245, 251–5
EF-hand, 252–5
high affinity, 251–5
low affinity, 245, 251
protozoan endoplasmic reticulum, 245
Calmodulin, 252–3, 255
Calmodulin-binding proteins, 252
Calmodulin-like domain protein kinases
(CDPKs), 253
Calnexin, 245
Calreticulin, 245
Calsequestrin, 245
cAMP, 197
signaling, 256–65
adenylyl cyclases, 257–9
cAMP-dependent protein kinases (PKA), 257–8
Capillaria philippinensis, 437
chemotherapy, 456
Carbamoyl phosphate synthetase II (CPSII), 218,
220, 222
Carbohydrate storage, apicomplexans, 166–8
Carboxypeptidases, 173–4
Cathepsin B, 180
Cathepsin D, 180
Cathepsin L, 180
Ce21, 371
Cell-cycle regulation, trypanosomes, 76
Cestodes, 438
chemotherapy, 458–60
immune evasion, 302
nervous system, 385, 386
neurotransmitters, 384, 387–92
osmoregulatory ducts, 302
purine/pyrimidine metabolism, 206, 222, 301
scolex, 299
tegument, 297, 298–300
biochemistry/molecular biology, 299–300
digestive functions, 300
inorganic ion transport, 301
nutrient absorption, 300–1
osmoregulation, 301–2
structure, 298–9
cGMP, 197
signaling, 256–65
guanylyl cyclases, 257, 258, 259
Chagas’ disease, see Trypanosoma cruzi
Chemotherapeutic agents, 434–6
development strategies, 436–7
historical aspects, 433, 436, 439–41
ideal properties, 437
in vitro ORFeome analysis, 18
resistance, 397–431, 438
apicomplexans, 399–413
clinical implications, 428–31
Cryptosporidium, 412–13
DNA-based diagnostic assays, 429
Eimeria, 412
kinetoplastids, 413–23
Leishmania virulence, 116–17
mechanisms, 398, 399
Plasmodium, 399–412, 443, 444, 445, 446
Toxoplasma gondii, 412
treatment principles, 437–9
see also Antihelmintics; Antimalarial drugs
Chlorocycloguanil, 409
Chloroquine, 398, 436, 439, 441, 442, 443
mode of action, 401–2, 403, 438, 443
resistance, 400–5, 439, 443, 446
molecular basis, 402–5
structure, 401, 440
Choline uptake, 301
Cholinergic receptor antihelmintics, 368–9, 388–9
single-channel currents activation, 369
Cholinesterase, 366
antihelmintic agent antagonists, 367, 368, 389
Chromatin:
diminution, 23
transcription-related remodelling, 48
Chromosomes, 6
karyotyping, 6–7
sequencing, 11–13
Cinchona bark, 439
Citric acid (TCA) cycle:
amino acid metabolism, 183, 184, 185
helminths, 345, 352
Plasmodium falciparum, 164–5
ClC channels, 331–2
ClC-1, 331
ClC-2, 331
CLH-1, 331, 332
CLH-3b, 332
Clindamycin, 446
resistance, 412
Clonorchis sinensis:
chemotherapy, 458
pyrimidine metabolism, 222