trans

482 INDEX
Pyrimidine transport, 200–7
Amitochondriates, 206
helminths, 206–7
Trypanosoma brucei, 204–5
Pyrimidines, 197, 198
Pyrophosphate-linked (PPi) acetate kinase, 134
Pyrophosphate-linked (PPi) phosphofructokinase,
133, 134
Pyruvate dehydrogenase, 349
Plasmodium falciparum, 165
Pyruvate dehydrogenase complex, 133, 349–50,
351, 355
Pyruvate dikinase, 130, 134
Pyruvate ferredoxin oxidoreductase, 132, 133, 165,
284, 424
drug targeting, 284
Pyruvate kinase, 130, 344
Plasmodium falciparum, 159
trypanosomes, 148
Pyruvate phosphate dikinase, 148–9
Pyruvate transporter, 144
Qinghaosu, 411, 439
Quinacrine, 436, 439
resistance, 425
Quinidine, 442, 443
Quinine, 433, 439, 442–3, 446
resistance, 406–7
structure, 401, 440
Quisqualate, 373
structure, 361
RACK1, 252
Reference strains, genome sequencing, 13–14
Reservosome, 180
Reticulocalbin, 245
Rhodoquinone, 348–9, 350
Ribonucleotide reductase, 198, 209, 219,
220, 222
Ribozymes, 33
rif genes, 107
RNA cis-splicing:
lariat intermediate, 31, 33
mechanism, 32
splice site bridging complexes, 34, 35
trypanosomes, 75
RNA degradation pathways, 71–2
cap removal, 72
EP genes, 81–3
nonsense-mediated decay, 71
poly(A) tail degradation, 71
trypanosomes, 76–80, 84–5
RNA editing, 37–44, 281
guide RNAs (gRNAs), 39, 41–2
historical background, 37–8
in vitro systems, 42, 43
kinetoplast RNA, 38–9
mechanism, 39
models, 39–41
cleavage–ligation, 40
transesterification, 40–1
regulatory proteins, 42–3
role in gene expression, 43
therapeutic targeting, 43
RNA interference (double-stranded
RNA-mediated gene knockouts), 18
RNA pol I, 47, 73, 98
-amanitin resistance, 49
transcription machinery, 55–6
transcription termination mechanism,
55
RNA pol II, 47, 49, 57, 59, 61, 63, 70, 81
RNA pol III, 48, 49, 60, 63
RNA polymerases, 47–8
RNA processing, 29, 69
see also Post-transcriptional regulation
RNA trans-splicing, 29–37
biological function, 35–7
evolutionary origin, 31
historical background, 29–30
mechanism, 32, 33–5
phylogenetic distribution, 30–2
polycistronic transcription, 35–7
protein coding genes, 48–9
splice site bridging complexes, 34,
35
spliced leader (SL) RNA to pre-mRNA,
59
therapeutic applications, 32
trypanosomes, 75–6
Y-branched intermediate, 31
RPA1,76
RPA2,76
Saccharomyces cerevisiae:
genome, 69
promoter structure, 51–2
telomere position effect (TPE), 100–1
SAG1,59
Salicylhydroxamic acid (SHAM), 163
Salinomycin, 412
Salvarsan, 419
Sand fly vectors, 112, 113
Sarcalumenin, 245