trans

INDEX 481
Procyclin genes:
expression sites (procyclin ES):
-amanitin-resistant transcription, 49, 50
promoter DNA-protein interactions, 54, 55
promoter structures, 52
termination determinants, 55
transcription regulation, 51
mRNA translation/degradation, 81–3
transcription regulation, 78, 79
Procyclins (procyclic acidic repetitive proteins;
PARPS), 74, 93, 226–8
cell cycle-specific expression, 228
glycosylphosphatidylinositol (GPI) anchors, 93,
227, 228
structure, 93, 227–8
Proguanil, 440, 442, 444
mode of action, 440–1, 444
resistance, 444
Proline:
catabolism, 183, 184
transport, 172
Prolyl hydroxylase, 353
Promoters, 51–4
DNA-protein interactions, 54–5
spliced leader (SL) RNA genes, 60, 61
U small nuclear RNA genes, 59, 60
Propyl gallate, 163
Proteases, see Proteinases
Proteasome, 73, 85, 177–8, 189
role in protozoan differentiation, 180
Protein kinase A, 370
Protein kinase C, 255, 370
calcium-binding, 251–2
Protein kinases, 265
intracellular signaling, 265
structure, 266
Protein metabolism, 171–94
Protein phosphatases, 265, 273–4
apicomplexans, 273–4
intracellular signaling, 265
kinetoplastids, 274
Proteinase inhibitors, 179, 330
Proteinases (endopeptidases; proteases), 174
chemotherapy targets, 181–2
developmental regulation, 180
functions, 179–81
helminths, 178–9
immune response, 173
nematodes, 329, 330
protozoa, 174–8
virulence factors, 180–1
Proteolytic enzymes, 173–82
Proteome analysis, 17, 18
Proteophosphoglycan, 239
cell-associated (mPPG), 239
filamentous (fPPG), 239
Protonephridial (flame cell) system, 303, 311
Protozoa, 437
expressed sequence tag (EST) datasets, 9
genomes, 4, 5, 21–2
size/organization, 18, 20
pulsed field gel electrophoresis (PFGE)
karyotyping, 7
whole genome shotgun sequencing, 11
Pseudoterranova decipiens, 331
Psoroptes ovis,26
Pteridine reductase (PTR1), 116, 117
Pterin metabolism, 408
Pulsed field gel electrophoresis (PFGE)
karyotyping, 7
Purine metabolism, 197–8, 207–18
amitochondriates, 215–17
Apicomplexa, 209–12
enzymes, 199
helminths, 217–18
cestodes, 301
Kinetoplastida, 212–15
Leishmania drug targets, 418, 452
salvage/interconversion pathways,
207–8
Purine nucleoside phosphorylase (PNP), 208, 209,
211
Purine transport, 200–7
Apicomplexa, 201–3
helminths, 206–7
Kinetoplastida, 203–5
Purines, 197–8
Putrescine, 189
Pyrantel, 388, 456
mode of action, 359, 368
resistance, 428
structure, 359
Pyrimethamine, 219, 430, 440, 442, 446
mode of action, 438
resistance, 399, 407, 412
Pyrimidine metabolism, 197–8, 218–22
amitochondriates, 221–2
Apicomplexa, 219–20
cestodes, 301
enzymes, 199
helminths, 222
Kinetoplastida, 220–1