trans

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ACKNOWLEDGMENTS
The authors thank the National Institute of
Allergy and Infectious Disease for their support
through grants AI23682, AI46416, and AI44138.
FURTHER READING
Aronov, A.M., Munagala, N.R., Ortiz De Montellano,
P.R., Kuntz, I.D. and Wang, C.C. (2000). Rational
design of selective submicromolar inhibitors
of Tritrichomonas foetus hypoxanthine–
guanine–xanthine phosphoribosyltransferase.
Biochemistry 39, 4684–4691.
Berens, R.L., Krug, E.C. and Marr, J. J. (1995). Purine
and pyrimidine metabolism. In: Marr, J.J. and
Muller, M. (eds). Biochemistry and Molecular
Biology of Parasites, London: Academic Press,
pp. 323–336.
Carter, N.S., Ben Mamoun, C., Liu, W. et al. (2000).
Isolation and functional characterization of
the PfNT1 nucleoside transporter gene from
Plasmodium falciparum. J. Biol. Chem. 275,
10683–10691.
Carter, N.S., Landfear, S.M. and Ullman, B. (2001).
Nucleoside transporters of parasitic protozoa.
Trends Parasitol. 17, 142–145.
Donald, R.G., Carter, D., Ullman, B. and Roos, D.S.
(1996). Insertional tagging, cloning, and expression
of the Toxoplasma gondii hypoxanthinexanthine-guanine
phosphoribosyltransferase
gene. Use as a selectable marker for stable transformation.
J. Biol. Chem. 271, 14010–14019.
European Bioinformatics Institute (2002). Parasite
genomes Wu-Blast2 (Submission Form). http://
www.ebi.ac.uk/blast2/parasites.html
Gao, G., Nara, T., Nakajima-Shimada, J. and Aoki, T.
(1999). Novel organization and sequences of five
genes encoding all six enzymes for de novo
pyrimidine biosynthesis in Trypanosoma cruzi.
J. Mol. Biol. 285, 149–161.
Hall, S.T., Hillier, C.J. and Gero, A.M. (1996).
Crithidia luciliae: regulation of purine nucleoside
transport by extracellular purine concentrations.
Exp. Parasitol. 83, 314–321.
Hwang, H.Y. and Ullman, B. (1997). Genetic analysis
of purine metabolism in Leishmania donovani.
J. Biol. Chem. 272, 19488–19496.
Kicska, G.A., Tyler, P.C., Evans, G.B., Furneaux, R.H.,
Schramm, V.L. and Kim, K. (2002). Purine-less
death in Plasmodium falciparum induced by
immucillin-H, a transition state analogue of
purine nucleoside phosphorylase. J. Biol. Chem.
277, 3226–3231.
Krug, E.C., Marr, J.J. and Berens, R.L. (1989). Purine
metabolism in Toxoplasma gondii. J. Biol. Chem.
264, 10601–10607.
Landfear, S.M. (2001). Molecular genetics of
nucleoside transporters in Leishmania and
African trypanosomes. Biochem. Pharmacol. 62,
149–155.
Marr, J.J. and Berens, R.L. (1983). Pyrazolopyrimidine
metabolism in the pathogenic Trypanosomatidae.
Mol. Biochem. Parasitol. 7, 339–356.
Marr, J. J. and Berens, R.L. (1986). Purine and pyrimidine
metabolism in Leishmania. In: Chang, K.-P.
and Bry, R.S. (eds). Leishmaniasis, New York:
Academic Press, pp. 65–79.
Plasmodium falciparum Genome Project (2002).
Plasmodb: the Plasmodium genome resource.
http://plasmodb.org/
Schumacher, M.A., Scott, D.M., Mathews, H. et al.
(2000). Crystal structures of Toxoplasma gondii
adenosine kinase reveal a novel catalytic mechanism
and prodrug binding. J. Mol. Biol. 298,
875–893.
Schwartzman, J.D. and Pfefferkorn, E.R. (1981).
Pyrimidine synthesis by intracellular Toxoplasma
gondii. J. Parasitol. 67, 150–158.
Shi, W., Munagala, N.R., Wang, C.C. et al. (2000).
Crystal structures of Giardia lamblia guanine
phosphoribosyltransferase at 1.75 Å. Biochemistry
39, 6781–6790.
Shih, S., Hwang, H.Y., Carter, D., Stenberg, P. and
Ullman, B. (1998). Localization and targeting of
the Leishmania donovani hypoxanthine–guanine
phosphoribosyltransferase to the glycosome.
J. Biol. Chem. 273, 1534–1541.
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