BNF for Children 2011-2012

156 3.4.1 Antihistamines BNFC 2011–20123 Respiratory systemAlimemazine (Non-proprietary) ATablets, alimemazine tartrate 10 mg, net price 28-tabpack = £4.28. Label: 2Oral Solution, alimemazine tartrate 7.5 mg /5 mL, netprice 100 mL = £6.83; 30 mg/5 mL, 100-mL = £7.55.Label: 2CHLORPHENAMINE MALEATE(Chlorpheniramine maleate)Cautions see notes aboveContra-indications see notes aboveHepatic impairment see notes abovePregnancy see notes aboveBreast-feeding see notes aboveSide-effects see notes above; also exfoliativedermatitis and tinnitus reported; injections may causetransient hypotension or CNS stimulation and may beirritantLicensed use syrup not licensed for use in childrenunder 1 year; tablets not licensed for use in childrenunder 6 years; injection not licensed for use inneonatesIndication and doseSymptomatic relief of allergy such as hay fever,urticaria. By mouthChild 1 month–2 years 1 mg twice dailyChild 2–6 years 1 mg every 4–6 hours, max. 6 mgdailyChild 6–12 years 2 mg every 4–6 hours, max.12 mg dailyChild 12–18 years 4 mg every 4–6 hours, max.24 mg dailyEmergency treatment of anaphylactic reactions,symptomatic relief of allergy. By intramuscular or intravenous injectionChild under 6 months 250 micrograms/kg (max.2.5 mg), repeated if required up to 4 times in 24hoursChild 6 months–6 years 2.5 mg, repeated ifrequired up to 4 times in 24 hoursChild 6–12 years 5 mg, repeated if required up to4 times in 24 hoursChild 12–18 years 10 mg, repeated if required upto 4 times in 24 hoursAdministration for intravenous injection, give over 1minute; if small dose required, dilute with SodiumChloride 0.9%Chlorphenamine (Non-proprietary)Tablets, chlorphenamine maleate 4 mg, net price 28 =£1.01. Label: 2Dental prescribing on NHS Chlorphenamine tablets may beprescribedOral solution, chlorphenamine maleate 2 mg/5 mL,net price 150 mL = £2.51. Label: 2Note Sugar-free versions are available and can be ordered byspecifying ‘sugar-free’ on the prescriptionDental prescribing on NHS Chlorphenamine oral solutionmay be prescribedInjection A 1 , chlorphenamine maleate 10 mg/mL,net price 1-mL amp = £1.791. A restriction does not apply where administration is forsaving life in emergencyPiriton c (GSK Consumer Healthcare)Tablets, yellow, scored, chlorphenamine maleate4 mg, net price 28 = £1.62. Label: 2Syrup, chlorphenamine maleate 2 mg/5 mL, net price150 mL = £2.39. Label: 2HYDROXYZINE HYDROCHLORIDECautions see notes above; also susceptibility to QTintervalprolongationContra-indications see notes aboveHepatic impairment reduce daily dose by one-third;see also notes aboveRenal impairment reduce daily dose by halfPregnancy toxicity in animal studies with high doses;see also notes aboveBreast-feeding see notes aboveSide-effects see notes aboveLicensed use Ucerax c syrup not licensed for use inchildren under 1 yearIndication and dosePruritus. By mouthChild 6 months–6 years initially 5–15 mg atnight, increased if necessary to 50 mg daily in 3–4divided dosesChild 6–12 years initially 15–25 mg at night,increased if necessary to 50–100 mg daily in 3–4divided dosesChild 12–18 years initially 25 mg at night,increased if necessary to 100 mg in 3–4 divideddosesAtarax c (Alliance) ATablets, both f/c, hydroxyzine hydrochloride 10 mg(orange), net price 84-tab pack = £2.18; 25 mg (green),28-tab pack = £1.17. Label: 2Ucerax c (UCB Pharma) ATabletsD, f/c, scored, hydroxyzine hydrochloride25 mg, net price 25-tab pack = £1.22. Label: 2Syrup, hydroxyzine hydrochloride 10 mg/5 mL. Netprice 200-mL pack = £1.78. Label: 2KETOTIFENCautions see notes aboveContra-indications see notes aboveHepatic impairment see notes abovePregnancy see notes aboveBreast-feeding see notes aboveSide-effects see notes above; also irritability, nervousness;less commonly cystitis; rarely weight gain;very rarely Stevens-Johnson syndromeIndication and doseSymptomatic relief of allergy such as allergicrhinitis. By mouthChild 3–18 years 1 mg twice daily