BNF for Children 2011-2012

392 6.7.4 Somatomedins BNFC 2011–2012Indication and doseGrowth failure in children with severe primaryinsulin-like growth factor-I deficiency. By subcutaneous injectionChild 2–18 years initially 40 micrograms/kgtwice daily for 1 week, if tolerated increase dose insteps of 40 micrograms/kg to max. 120 micrograms/kgtwice daily; discontinue if no responsewithin 1 yearCounselling Dose should be administered just before orafter food; do not increase dose if a dose is missedNote Reduce dose if hypoglycaemia occurs despite adequatefood intake; withhold injection if patient unable to eatIncrelex c (Ipsen) AInjection, mecasermin 10 mg/mL, net price 4-mL vial= £605.00. Counselling, administrationExcipients include benzyl alcohol (avoid in neonates, see Excipients,p. 2)6 Endocrine system