BNF for Children 2011-2012

194 4.6 Drugs used in nausea and vertigo BNFC 2011–20124 Central nervous systemCyclizine (Non-proprietary)Suppositories, 12.5 mg, 25 mg, 50 mg, 100 mg.Available from ‘special-order’ manufacturers or specialistimporting companies, see p. 809PROMETHAZINE HYDROCHLORIDECautions see notes in section 3.4.1Contra-indications see Promethazine Hydrochloride,section 3.4.1Hepatic impairment see notes in section 3.4.1Renal impairment see Promethazine Hydrochloride,section 3.4.1Pregnancy see notes in section 3.4.1Breast-feeding see notes in section 3.4.1Side-effects see Promethazine Hydrochloride, section3.4.1 but more sedatingIndication and doseNausea and vomiting. By mouthChild 2–5 years 5 mg at bedtime on night beforetravel, repeat following morning if necessaryChild 5–10 years 10 mg at bedtime on nightbefore travel, repeat following morning if necessaryChild 10–18 years 20–25 mg at bedtime on nightbefore travel, repeat following morning if necessaryAllergy and urticaria section 3.4.1Sedation section 4.1.1PreparationsSection 3.4.1PROMETHAZINE TEOCLATECautions section 3.4.1; severe coronary artery disease;asthma, bronchitis, bronchiectasis, Reye’ssyndromeContra-indications section 3.4.1Hepatic impairment section 3.4.1Renal impairment use with cautionPregnancy section 3.4.1Breast-feeding section 3.4.1Side-effects section 3.4.1Licensed use not licensed to treat vomiting ofpregnancyIndication and doseNausea, vomiting, labyrinthine disorders. By mouthChild 5–10 years 12.5–37.5 mg dailyChild 10–18 years 25–75 mg daily (max. 100 mg)Motion sickness prevention. By mouthChild 5–10 years 12.5 mg at bedtime on nightbefore travel or 12.5 mg 1–2 hours before travelChild 10–18 years 25 mg at bedtime on nightbefore travel or 25 mg 1–2 hours before travelMotion sickness treatment. By mouthChild 5–10 years 12.5 mg at onset, then 12.5 mgat bedtime for 2 daysChild 10–18 years 25 mg at onset, then 25 mg atbedtime for 2 daysSevere vomiting during pregnancy. By mouth25 mg at bedtime increased if necessary to max.100 mg daily (but see also Vomiting DuringPregnancy, p. 192)Avomine c (Manx)Tablets, scored, promethazine teoclate 25 mg, netprice 10-tab pack = £1.13; 28-tab pack = £3.13.Label: 2Phenothiazines and related drugsCHLORPROMAZINEHYDROCHLORIDECautions see Chlorpromazine Hydrochloride, section4.2.1Contra-indications see notes in section 4.2.1Hepatic impairment see notes in section 4.2.1Renal impairment see notes in section 4.2.1Pregnancy see notes in section 4.2.1Breast-feeding see notes in section 4.2.1Side-effects see Chlorpromazine Hydrochloride, section4.2.1Indication and doseNausea and vomiting of terminal illness (whereother drugs are unsuitable). By mouthChild 1–6 years 500 micrograms/kg every 4–6hours; max. 40 mg dailyChild 6–12 years 500 micrograms/kg every 4–6hours; max. 75 mg dailyChild 12–18 years 10–25 mg every 4–6 hours. By deep intramuscular injectionChild 1–6 years 500 micrograms/kg every 6–8hours; max. 40 mg dailyChild 6–12 years 500 micrograms/kg every 6–8hours; max. 75 mg dailyChild 12–18 years initially 25 mg then 25–50 mgevery 3–4 hours until vomiting stopsPreparationsSection 4.2.1DROPERIDOLCautions section 4.2.1; also chronic obstructivepulmonary disease or respiratory failure; electrolytedisturbances; history of alcohol abuse; continuouspulse oximetry required if risk of ventricular arrhythmia—continuefor 30 minutes following administration;interactions: Appendix 1 (droperidol)Contra-indications section 4.2.1; QT-interval prolongation(avoid concomitant administration of drugs