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BNF for Children 2011-2012

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742 Appendix 1: Interactions <strong>BNF</strong>C <strong>2011</strong>–<strong>2012</strong>Zonisamide. Antidepressants (continued)lowered); avoid concomitant use of antiepilepticswith .St John’s wortAntiepileptics: plasma concentration of zonisamidereduced by carbamazepine, phenobarbital andphenytoin. Antimalarials: possible increased risk of convulsionswhen antiepileptics given with chloroquine andhydroxychloroquine; anticonvulsant effect of antiepilepticsantagonised by .mefloquine. Antipsychotics: anticonvulsant effect of antiepilepticsantagonised by .antipsychotics (convulsive thresholdlowered). Orlistat: possible increased risk of convulsions whenantiepileptics given with .orlistatZopiclone see Anxiolytics and HypnoticsZuclopenthixol see AntipsychoticsAppendix 1: Interactions

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