BNF for Children 2011-2012

BNFC 2011–2012 13.10.3 Antiviral preparations 591Mycota c (Thornton & Ross)Cream, zinc undecenoate 20%, undecenoic acid 5%,net price 25 g = £1.64Excipients include fragranceDoseTreatment of athlete’s footApply twice daily continuing for 7 days after lesions havehealedPrevention of athlete’s footApply once dailyPowder, zinc undecenoate 20%, undecenoic acid 2%,net price 70 g = £2.22Excipients include fragranceDoseTreatment of athlete’s footApply twice daily continuing for 7 days after lesions havehealedPrevention of athlete’s footApply once dailySpray application, undecenoic acid 3.9%, dichlorophen0.4% (pressurised aerosol pack), net price100 mL = £2.46Excipients include fragranceDoseTreatment of athlete’s footApply twice daily continuing for 7 days after lesions havehealedPrevention of athlete’s footApply once daily13.10.3 Antiviral preparationsSee section 12.3.2 for drugs used in herpetic stomatitis,section 13.5.1 for eczema herpeticum, and section11.3.3 for viral infections of the eye.Aciclovir cream is used for the treatment of initial andrecurrent labial, cutaneous, and genital herpes simplexinfections in children; treatment should begin as early aspossible. Systemic treatment is necessary for buccal orvaginal infections or if cold sores recur frequently (fordetails of systemic use see section 5.3.2.1).Herpes labialis Aciclovir cream can be used for thetreatment of initial and recurrent labial herpes simplexinfections (cold sores). It is best applied at the earliestpossible stage, usually when prodromal changes ofsensation are felt in the lip and before vesicles appear.Penciclovir cream is also licensed for the treatment ofherpes labialis; it needs to be applied more frequentlythan aciclovir cream. These creams should not be usedin the mouth.ACICLOVIR(Acyclovir)Cautions avoid contact with eyes and mucous membranesPregnancy not known to be harmful—manufacturersadvise use only when potential benefit outweighs risk;limited absorption from topical aciclovir preparationsSide-effects transient stinging or burning; occasionallyerythema, itching or drying of the skinLicensed use licensed for use in children (age rangenot specified by manufacturer)Indication and doseHerpes simplex infectionsApply to lesions every 4 hours (5 times daily) for 5–10 days, starting at first sign of attackHerpes simplex and varicella–zoster infectionssection 5.3.2.1Eye infections section 11.3.31Aciclovir (Non-proprietary) ACream, aciclovir 5%, net price 2 g = £1.10, 10 g =£1.81Excipients include propylene glycolBrands include Zuvogen c (excipients include cetyl alcohol,propylene glycol)Dental prescribing on NHS Aciclovir Cream may beprescribed1. A 2-g tube and a pump pack are on sale to the public for thetreatment of cold soresZovirax c (GSK) ACream, aciclovir 5%, net price 2 g = £4.63, 10 g =£13.96Excipients include cetostearyl alcohol, propylene glycolPENCICLOVIRCautions avoid contact with eyes and mucous membranesSide-effects transient stinging, burning, numbness;hypersensitivity reactions also reportedLicensed use not licensed for use in children under12 yearsVectavir c (Novartis Consumer Health) ACream, penciclovir 1%, net price 2 g = £4.20Excipients include cetostearyl alcohol, propylene glycolDoseHerpes labialisApply to lesions every 2 hours during waking hours for 4days, starting at first sign of attackDental prescribing on NHS May be prescribed as PenciclovirCream13.10.4 Parasiticidal preparationsSuitable quantities of parasiticidal preparationsScalp (headlice)Skin Lotions Cream rinsescreams— 50–100 mL 50–100 mLBody (scabies) 30–60 g 100 mL —Body (crab lice) 30–60 g 100 mL —These amounts are usually suitable for a child 12–18years for single application13 Skin