BNF for Children 2011-2012

BNFC 2011–2012 13.10.1 Antibacterial preparations 587longed use; leucopenia reported (monitor bloodcount)Licensed use no age range specified by manufacturerbut see contra-indications, aboveIndication and doseProphylaxis and treatment of infection in burnwounds, for conservative management of finger-tipinjuries see under preparation belowAdjunct to short-term treatment of infection inpressure sores, adjunct to prophylaxis ofinfection in skin graft donor sites and extensiveabrasions consult product literature for detailsFlamazine c (S&N Hlth.) ACream, silver sulfadiazine 1%, net price 20 g = £2.91,50 g = £3.85, 250 g = £10.32, 500 g = £18.27Excipients include cetyl alcohol, polysorbates, propylene glycolDoseBurnsChild 1 month–18 years apply daily or more frequentlyif very exudativeFinger-tip injuriesChild 1 month–18 years apply every 2–3 daysNote apply with sterile applicator13.10.1.2 Antibacterial preparations alsoused systemicallySodium fusidate is a narrow-spectrum antibacterialused for staphylococcal infections. For the role of sodiumfusidate in the treatment of impetigo see p. 585.Metronidazole is used topically to treat rosacea and toreduce the odour associated with anaerobic infections;oral metronidazole (section 5.1.11) is used to treatwounds infected with anaerobic bacteria.Angular cheilitis An ointment containing sodiumfusidate is used in the fissures of angular cheilitiswhen associated with staphylococcal infection. Forfurther information on angular cheilitis, see p. 545.FUSIDIC ACIDCautions see notes above; avoid contact with eyesSide-effects rarely hypersensitivity reactionsLicensed use licensed for use in children (age rangenot specified by manufacturer)Indication and doseStaphylococcal skin infectionsApply 3–4 times daily, usually for 7 daysPenicillin-resistant staphylococcal infectionssection 5.1.7Staphylococcal eye infectionssection 11.3.1Fucidin c (LEO) ACream, fusidic acid 2%, net price 15 g = £1.92, 30 g =£3.64Excipients include butylated hydroxyanisole, cetyl alcoholOintment, sodium fusidate 2%, net price 15 g = £2.23,30 g = £3.79Excipients include cetyl alcohol, wool fatDental prescribing on NHS May be prescribed as SodiumFusidate ointmentMETRONIDAZOLECautions avoid exposure to strong sunlight or UV lightSide-effects skin irritationLicensed use Acea c and Anabact c not licensed foruse in children under 12 years; Noritate c notlicensed for use in children under 16 years;Metrogel c , Metrosa c , Rosiced c , Rozex c , andZyomet c not licensed for use in childrenIndication and doseMalodorous tumours and woundsFor dose see preparationsRosacea (see also section 13.6)For dose see preparationsHelicobacter pylori eradicationsection 1.3Anaerobic infectionssection 5.1.11 and section 7.2.2Protozoal infectionssection 5.4.2Acea c (Ferndale) AGel, metronidazole 0.75%, net price 40 g = £9.95Excipients include disodium edetate, hydroxybenzoates (parabens)DoseAcute inflammatory exacerbations of rosaceaChild 1–18 years apply thinly twice dailyAnabact c (CHS) AGel, metronidazole 0.75%, net price 15 g = £4.47, 30 g= £7.89Excipients include hydroxybenzoates (parabens), propylene glycolDoseMalodorous fungating tumours and skin ulcersApply to clean wound 1–2 times daily and cover withnon-adherent dressingMetrogel c (Galderma) AGel, metronidazole 0.75%, net price 40 g = £6.86Excipients include hydroxybenzoates (parabens), propylene glycolDoseAcute inflammatory exacerbations of rosaceaChild 1–18 years apply thinly twice dailyMalodorous fungating tumoursApply to clean wound 1–2 times daily and cover withnon-adherant dressingMetrosa c (Linderma) AGel, metronidazole 0.75%, net price 40 g = £19.90Excipients include propylene glycolDoseAcute exacerbation of rosaceaChild 1–18 years apply thinly twice daily13 Skin