BNF for Children 2011-2012

60 1.6.2 Stimulant laxatives BNFC 2011–20121 Gastro-intestinal systemWith docusate sodium (as co-danthrusate)Co-danthrusate (Non-proprietary) ACapsules, co-danthrusate 50/60 (dantron 50 mg,docusate sodium 60 mg). Net price 63-cap pack =£15.87. Label: 14, (urine red)Brands include Normax c DDose. By mouthChild 6–12 years 1 capsule at night (restricted indications,see notes above)Child 12–18 years 1–3 capsules at night (restrictedindications, see notes above)Suspension, yellow, co-danthrusate 50/60 (dantron50 mg, docusate sodium 60 mg/5 mL). Net price200 mL = £8.75. Label: 14, (urine red)Brands include Normax cDose. By mouthChild 6–12 years 5 mL at night (restricted indications,see notes above)Child 12–18 years 5–15 mL at night (restricted indications,see notes above)DOCUSATE SODIUM(Dioctyl sodium sulphosuccinate)Cautions see notes above; do not give with liquidparaffinContra-indications see notes above; also for rectalpreparations, haemorrhoids or anal fissurePregnancy not known to be harmful—manufactureradvises cautionBreast-feeding present in milk following oral administration—manufactureradvises caution; rectaladministration not known to be harmfulSide-effects see notes above; also rashLicensed use adult oral solution and capsules notlicensed for use in children under 12 yearsIndication and doseConstipation. By mouthChild 6 months–2 years 12.5 mg 3 times daily,adjusted according to response (use paediatric oralsolution)Child 2–12 years 12.5–25 mg 3 times daily,adjusted according to response (use paediatric oralsolution)Child 12–18 years up to 500 mg daily in divideddoses, adjusted according to responseNote Oral preparations act within 1–2 days; response torectal administration usually occurs within 20 minutesAdjunct in abdominal radiological procedures. By mouthChild 12–18 years 400 mg with barium mealAdministration for administration by mouth, solutionmay be mixed with milk or squashDioctyl c (UCB Pharma)Capsules, yellow/white, docusate sodium 100 mg,net price 30-cap pack = £1.92, 100-cap pack = £6.40Docusol c (Typharm)Adult oral solution, sugar-free, docusate sodium50 mg/5 mL, net price 300 mL = £5.49Paediatric oral solution, sugar-free, docusate sodium12.5 mg/5 mL, net price 300 mL = £5.29Rectal preparationsNorgalax Micro-enema c (Norgine)Enema, docusate sodium 120 mg in 10-g single-dosedisposable packs. Net price 10-g unit = 57pDose. By rectumChild 12–18 years 1 enema as a single doseGLYCEROL(Glycerin)Indication and doseConstipation. By rectumChild 1 month–1 year 1-g suppository as requiredChild 1–12 years 2-g suppository as requiredChild 12–18 years 4-g suppository as requiredGlycerol Suppositories, BP(Glycerin Suppositories)Suppositories, gelatin 140 mg, glycerol 700 mg, purifiedwater to 1 g, net price 12 = £1.27 (1 g), £1.29 (2 g),£1.48 (4 g)Administration Moisten with water before insertionSENNACautions see notes aboveContra-indications see notes abovePregnancy see Pregnancy, p. 57Breast-feeding not known to be harmfulSide-effects see notes aboveLicensed use tablets not licensed for use in childrenunder 6 years; syrup not licensed for use in childrenunder 2 yearsIndication and doseConstipation for dose see under preparationsNote Onset of action 8–12 hours; initial dose should belowSenna (Non-proprietary)Tablets, total sennosides (calculated as sennoside B)7.5 mg. Net price 60 = £1.47Brands include Senokot c DDose. By mouthChild 2–4 years ½–2 tablets once daily, adjustedaccording to responseChild 4–6 years ½–4 tablets once daily, adjustedaccording to responseChild 6–18 years 1–4 tablets once daily, adjustedaccording to responseManevac c (HFA Healthcare)Granules, coated, senna fruit 12.4%, ispaghula 54.2%,net price 400 g = £7.45. Label: 25, counselling,administrationExcipients include sucrose 800 mg per level 5-mL spoonful of granulesDose. By mouthChild 12–18 years 1–2 level 5-mL spoonfuls at nightwith at least 150 mL water, fruit juice, milk, or warm drinkCounselling Preparations that swell in contact with liquidshould always be carefully swallowed with water or appropriatefluid and should not be taken immediately beforegoing to bed