BNF for Children 2011-2012

484 9.6.4 Vitamin D BNFC 2011–20129 Nutrition and bloodVitamin D dependent rickets; hypophosphataemicrickets; persistent hypocalcaemia due tohypoparathyroidism or pseudo-hypoparathyroidism(limited experience). By mouthChild 1 month–12 years initially 15 nanograms/kg (max. 250 nanograms) once daily, increased ifnecessary in steps of 5 nanograms/kg daily (max.250 nanograms) every 2–4 weeksChild 12–18 years initially 250 nanograms oncedaily increased if necessary in steps of 5 nanograms/kgdaily (max. 250 nanograms step) every2–4 weeks; usual dose 0.5–1 microgram dailyHypocalcaemia in dialysis patients (limitedexperience). By intravenous injectionChild 12–18 years initially 250–500 nanograms(approx. 10 nanograms/kg) 3 times a week,increased if necessary in steps of 2–5 nanograms/kg every 2–4 weeks; usual dose 0.5–3 micrograms3 times a weekAdministration For administration by mouth, injectionsolution may be given orally or contents ofcapsule administered by oral syringe; capsules containapprox. 0.168 mL of fluidFor administration by intravenous injection, injectionmay be given via catheter after dialysisCalcitriol (Non-proprietary) ACapsules, calcitriol 250 nanograms, net price 30-cappack = £18.04, 100-cap pack = £19.15; 500 nanograms,30-cap pack =£32.25, 100-cap pack = £25.76Rocaltrol c (Roche) ACapsules, calcitriol 250 nanograms (red/white), netprice 100 = £18.04; 500 nanograms (red), 100 =£32.25Calcijex c (Abbott) AInjection, calcitriol 1 microgram/mL, net price 1-mLamp = £5.14; 2 micrograms/mL, 1-mL amp = £10.28COLECALCIFEROL(Cholecalciferol, vitamin D 3)Cautions see under ErgocalciferolContra-indications see under ErgocalciferolPregnancy see under ErgocalciferolBreast-feeding see under ErgocalciferolSide-effects see under ErgocalciferolLicensed use Sandocal c + D 600 not licensed foruse in children under 2 years; Adcal-D3 c ,Calceos c , and Sandocal c + D 1200 not licensedfor use in children under 12 years; Cacit c D3,Calcichew-D 3cForte, Calcichew-D 3c500 mg/400 unit, and Kalcipos-D c not licensed for use inchildren (age range not specified by manufacturers);Calfovit D3 c and Natecal D3 c not licensed for usein children under 18 yearsIndication and doseSee under Ergocalciferol and notes above—alternativeto Ergocalciferol, see also PharmacologicalStrengthsColecalciferolVarious formulations available from ‘special-order’manufacturers or specialist importing companies, seep. 809With calciumFor prescribing information on calcium, see section9.5.1Adcal-D c 3 (ProStrakan)Tablets (chewable), lemon or tutti-frutti flavour, calciumcarbonate 1.5 g (calcium 600 mg or Ca 2þ15 mmol), colecalciferol 10 micrograms (400 units),net price 56-tab pack = £3.89, 112-tab pack = £7.78.Label: 24Dissolve (effervescent tablets), lemon flavour, calciumcarbonate 1.5 g (calcium 600 mg or Ca 2þ15 mmol), colecalciferol 10 micrograms (400 units),net price 56-tab pack = £4.99. Label: 13Cacit c D3 (Warner Chilcott)Granules, effervescent, lemon flavour, calcium carbonate1.25 g (calcium 500 mg or Ca 2þ 12.5 mmol),colecalciferol 11 micrograms (440 units)/sachet, netprice 30-sachet pack = £4.06. Label: 13Calceos c (Galen)Tablets (chewable), lemon flavour, calcium carbonate1.25 g (calcium 500 mg or Ca 2þ 12.5 mmol), colecalciferol10 micrograms (400 units), net price 60-tabpack = £3.62. Label: 24Calcichew-D c 3 (Shire)Calcichew-D c3 tablets (chewable), orange flavour,calcium carbonate 1.25 g (calcium 500 mg or Ca 2þ12.5 mmol), colecalciferol 5 micrograms (200 units),net price 100-tab pack = £7.68. Label: 24Excipients include aspartame (section 9.4.1)Calcichew-D c3 Forte tablets (chewable), lemonflavour, calcium carbonate 1.25 g (calcium 500 mg orCa 2þ 12.5 mmol), colecalciferol 10 micrograms(400 units), net price 100-tab pack = £7.21. Label: 24Excipients include aspartame (section 9.4.1)Calcichew-D c3 500 mg/400 unit caplets, f/c, lemonflavour, calcium carbonate providing calcium 500 mg(Ca 2þ 12.5 mmol), colecalciferol 10 micrograms(400 units), net price 100-tab pack = £7.57Excipients include propylene glycol (see Excipients ,p. 2)Calfovit D3 c (Menarini)Powder, lemon flavour, calcium phosphate 3.1 g(calcium 1.2 g or Ca 2þ 30 mmol), colecalciferol20 micrograms (800 units), net price 30-sachet pack =£4.32. Label: 13, 21Kalcipos-D c (Meda) ATablets (chewable), calcium carbonate providingcalcium 500 mg (Ca 2þ 12.5 mmol), colecalciferol20 micrograms (800 units), net price 30-tab pack =£4.21. Label: 24Natecal D3 c (Chiesi)Tablets (chewable), (aniseed, peppermint, andmolasses flavour), calcium carbonate 1.5 g (calcium600 mg or Ca 2þ 15 mmol), colecalciferol 10 micrograms(400 units), net price 60-tab pack = £3.63.Label: 24Excipients include aspartame (section 9.4.1)Sandocal c +D (Novartis Consumer Health)Sandocal c +D 600 tablets, effervescent, orangeflavour, calcium lactate gluconate 1.36 g, calciumcarbonate 1.05 g, providing calcium 600 mg (Ca 2þ